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    Zfp119b zinc finger protein 119b [ Mus musculus (house mouse) ]

    Gene ID: 240120, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp119bprovided by MGI
    Official Full Name
    zinc finger protein 119bprovided by MGI
    Primary source
    MGI:MGI:2385323
    See related
    Ensembl:ENSMUSG00000062101 AllianceGenome:MGI:2385323
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF630 (zinc finger protein 630) and ZNF90 (zinc finger protein 90). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 1.1), liver E18 (RPKM 0.8) and 28 other tissues See more
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    Genomic context

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    See Zfp119b in Genome Data Viewer
    Location:
    17 D; 17 29.07 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56245373..56263186, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55938373..55956233, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2495 Neighboring gene zinc finger protein 959 Neighboring gene predicted gene, 41603 Neighboring gene ribosomal protein L21, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_42873 Neighboring gene STARR-positive B cell enhancer ABC_E4220 Neighboring gene STARR-positive B cell enhancer ABC_E7546 Neighboring gene STARR-positive B cell enhancer ABC_E2496 Neighboring gene predicted gene, 16712 Neighboring gene Epstein-Barr virus induced gene 3 Neighboring gene YJU2 splicing factor Neighboring gene src homology 2 domain-containing transforming protein D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC18735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 119b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310337.1 → NP_001297266.1  zinc finger protein 119b isoform 2

      See identical proteins and their annotated locations for NP_001297266.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154235
      Consensus CDS
      CCDS79564.1
      UniProtKB/TrEMBL
      A0A087WPI5
      Related
      ENSMUSP00000139791.2, ENSMUST00000189452.2
      Conserved Domains (3) summary
      COG5048
      Location:337 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain

    2. NM_146249.4 → NP_666361.1  zinc finger protein 119b isoform 1

      See identical proteins and their annotated locations for NP_666361.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC154235
      Consensus CDS
      CCDS37659.1
      UniProtKB/TrEMBL
      Q8K0G9
      Related
      ENSMUSP00000058300.8, ENSMUST00000056147.14
      Conserved Domains (5) summary
      smart00349
      Location:4 → 46
      KRAB; krueppel associated box
      COG5048
      Location:369 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:373 → 393
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 41
      KRAB; KRAB box
      pfam13465
      Location:413 → 438
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56245373..56263186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246456.3 → XP_011244758.1  zinc finger protein 119b isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:396 → 552
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:400 → 420
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:31 → 71
      KRAB; KRAB box
      pfam13465
      Location:356 → 381
      zf-H2C2_2; Zinc-finger double domain

    2. XM_011246457.3 → XP_011244759.1  zinc finger protein 119b isoform X2

      See identical proteins and their annotated locations for XP_011244759.1

      UniProtKB/TrEMBL
      A0A087WPI5
      Conserved Domains (3) summary
      COG5048
      Location:337 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain

    3. XM_017317472.3 → XP_017172961.1  zinc finger protein 119b isoform X2

      UniProtKB/TrEMBL
      A0A087WPI5
      Conserved Domains (3) summary
      COG5048
      Location:337 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:341 → 361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:297 → 322
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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