Tgif2 TGFB-induced factor homeobox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tgif2provided by MGI
Official Full Name: TGFB-induced factor homeobox 2provided by MGI
Primary source: MGI:MGI:1915299
See related: Ensembl:ENSMUSG00000062175 AllianceGenome:MGI:1915299
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 4921501K24; 5730599O09Rik
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including nodal signaling pathway; positive regulation of amacrine cell differentiation; and regulation of gastrulation. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; forelimb phalanx; genitourinary system; and sensory organ. Orthologous to human TGIF2 (TGFB induced factor homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 11.1), limb E14.5 (RPKM 10.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156681737..156697490)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (156839817..156855570)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
Title: Downregulation of TGIF2 is possibly correlated with neuronal apoptosis and autism-like symptoms in mice.
Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
Title: Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.
Gm14230 safeguards cellular juvenescence through recruiting the histone methyltransferase Ezh2 to Tgif2, thereby repressing the functional role of Tgif2 in cellular senescence.
Title: The juvenility-associated long noncoding RNA Gm14230 maintains cellular juvenescence.
Tgif2 plays an important role in the regulation of osteoblastic differentiation in vitro
Title: TGFβ-induced factor homeobox 2 blocks osteoblastic differentiation through targeting pSmad3/HDAC4/H4ac/Runx2 axis.
Tgifs play an important role in regulating basic energy metabolism in normal cells, and that this function of Tgifs is amplified in some cancers.
Title: TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth.
Studies indicate the reprogramming activity of TG-interacting factor 2 (TGIF2) and suggest a stepwise reprogramming paradigm.
Title: Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2.
Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect.
Title: Tgif1 and Tgif2 Repress Expression of the RabGAP Evi5l.
loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2
Title: Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.
Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation.
Title: Tgif1 and Tgif2 regulate Nodal signaling and are required for gastrulation.
TGIF2 is the molecular link between dorsoventral patterning of the endoderm and pancreatic specification.
Title: The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tgif2 (e-PCR), detects polymorphism
- UniSTS:469810

UniSTS:469811 (e-PCR)
- UniSTS:469811

Tgif2 (e-PCR), detects polymorphism
- UniSTS:469811

Tgif2 (e-PCR), detects polymorphism
- UniSTS:547379

NoName (e-PCR)
- UniSTS:234580

RH126967 (e-PCR)
- UniSTS:209771

RH127030 (e-PCR)
- UniSTS:209779

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nodal signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of amacrine cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: homeobox protein TGIF2

Names: 5'-TG-3'-interacting factor 2; TALE family homeobox; TGF-beta-induced transcription factor 2; TGFB-induced factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291124.1 → NP_001278053.1 homeobox protein TGIF2 isoform b

See identical proteins and their annotated locations for NP_001278053.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.

Source sequence(s)

AK029490, AL935150, BQ030806, CF731285

Consensus CDS

CCDS71173.1

UniProtKB/TrEMBL

Q3TZS1

Related

ENSMUSP00000073074.4, ENSMUST00000073352.10

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
NM_173396.3 → NP_775572.1 homeobox protein TGIF2 isoform a

See identical proteins and their annotated locations for NP_775572.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AK029490, AL935150, BQ030806

Consensus CDS

CCDS16969.1

UniProtKB/Swiss-Prot

Q8C0Y1

UniProtKB/TrEMBL

A2AVY9

Related

ENSMUSP00000096745.5, ENSMUST00000081335.13

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

156681737..156697490

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499353.3 → XP_006499416.1 homeobox protein TGIF2 isoform X1

See identical proteins and their annotated locations for XP_006499416.1

UniProtKB/Swiss-Prot

Q8C0Y1

UniProtKB/TrEMBL

A2AVY9

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_006499354.5 → XP_006499417.1 homeobox protein TGIF2 isoform X1

See identical proteins and their annotated locations for XP_006499417.1

UniProtKB/Swiss-Prot

Q8C0Y1

UniProtKB/TrEMBL

A2AVY9

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_036161592.1 → XP_036017485.1 homeobox protein TGIF2 isoform X2

UniProtKB/TrEMBL

Q3TZS1

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_006499351.5 → XP_006499414.1 homeobox protein TGIF2 isoform X1

See identical proteins and their annotated locations for XP_006499414.1

UniProtKB/Swiss-Prot

Q8C0Y1

UniProtKB/TrEMBL

A2AVY9

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_030250654.2 → XP_030106514.1 homeobox protein TGIF2 isoform X2

UniProtKB/TrEMBL

Q3TZS1

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_036161591.1 → XP_036017484.1 homeobox protein TGIF2 isoform X2

UniProtKB/TrEMBL

Q3TZS1

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain
XM_006499352.5 → XP_006499415.1 homeobox protein TGIF2 isoform X1

See identical proteins and their annotated locations for XP_006499415.1

UniProtKB/Swiss-Prot

Q8C0Y1

UniProtKB/TrEMBL

A2AVY9

Conserved Domains (1) summary

pfam05920
Location:36 → 75

Homeobox_KN; Homeobox KN domain