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    Patl2 protein associated with topoisomerase II homolog 2 (yeast) [ Mus musculus (house mouse) ]

    Gene ID: 67578, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Patl2provided by MGI
    Official Full Name
    protein associated with topoisomerase II homolog 2 (yeast)provided by MGI
    Primary source
    MGI:MGI:1914828
    See related
    Ensembl:ENSMUSG00000027233 AllianceGenome:MGI:1914828
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pat1a; 4930424G05Rik
    Summary
    Predicted to enable RNA binding activity and translation repressor activity. Acts upstream of or within negative regulation of cytoplasmic mRNA processing body assembly. Located in P-body and nucleus. Used to study ovarian disease. Orthologous to human PATL2 (PAT1 homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 1.1), ovary adult (RPKM 0.7) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Patl2 in Genome Data Viewer
    Location:
    2 E5; 2 60.53 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121950589..122016670, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122120108..122186189, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05545 Neighboring gene CTD small phosphatase like 2 Neighboring gene MAGE family member B3 Neighboring gene STARR-positive B cell enhancer ABC_E1597 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene STARR-seq mESC enhancer starr_05546 Neighboring gene STARR-positive B cell enhancer ABC_E512 Neighboring gene STARR-seq mESC enhancer starr_05550 Neighboring gene beta-2 microglobulin Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene ATP synthase F(0) complex subunit C1, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PATL2 is a key actor of oocyte maturation whose invalidation causes infertility in women and mice. Christou-Kent M, et al. EMBO Mol Med, 2018 May. PMID 29661911, Free PMC Article
    2. PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1. Zhang Z, et al. Development, 2023 Jun 15. PMID 37218508
    3. Distinct functions of maternal and somatic Pat1 protein paralogs. Marnef A, et al. RNA, 2010 Nov. PMID 20826699, Free PMC Article
    4. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
      Title: PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1.
    2. hPat1b localizes to P-bodies, while mPat1a-GFP is either found weakly in P-bodies or disperses P-bodies in a dominant-negative fashion.
      Title: Distinct functions of maternal and somatic Pat1 protein paralogs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables poly(G) binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytoplasmic mRNA processing body assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein PAT1 homolog 2
    Names
    PAT1-like protein 2
    protein PAT1 homolog a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026251.2 → NP_080527.2  protein PAT1 homolog 2

      See identical proteins and their annotated locations for NP_080527.2

      Status: VALIDATED

      Source sequence(s)
      AK010811, AL845457, BY714747, DV658440, DV660077
      Consensus CDS
      CCDS16653.1
      UniProtKB/Swiss-Prot
      A2ARM1, A6H5U9, Q9D5L4
      Related
      ENSMUSP00000028665.5, ENSMUST00000028665.5
      Conserved Domains (1) summary
      pfam09770
      Location:265 → 399
      PAT1; Topoisomerase II-associated protein PAT1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      121950589..122016670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319224.2 → XP_017174713.1  protein PAT1 homolog 2 isoform X1

      UniProtKB/Swiss-Prot
      A2ARM1, A6H5U9, Q9D5L4
      Conserved Domains (1) summary
      pfam09770
      Location:265 → 399
      PAT1; Topoisomerase II-associated protein PAT1

    2. XM_006500086.4 → XP_006500149.1  protein PAT1 homolog 2 isoform X2

      Conserved Domains (1) summary
      pfam09770
      Location:101 → 235
      PAT1; Topoisomerase II-associated protein PAT1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2ARM1.1 GenPept UniProtKB/Swiss-Prot:A2ARM1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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