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    Nkpd1 NTPase, KAP family P-loop domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69547, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nkpd1provided by MGI
    Official Full Name
    NTPase, KAP family P-loop domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916797
    See related
    Ensembl:ENSMUSG00000060621 AllianceGenome:MGI:1916797
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310015G09Rik
    Summary
    Predicted to be located in membrane. Orthologous to human NKPD1 (NTPase KAP family P-loop domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 25.1), lung adult (RPKM 2.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Nkpd1 in Genome Data Viewer
    Location:
    7 A3; 7 9.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (19251404..19258982)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19517491..19525057)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6520 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 3 Neighboring gene trafficking protein particle complex 6A Neighboring gene protein phosphatase 1, regulatory subunit 37 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene STARR-seq mESC enhancer starr_18207

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. Pinto CS, et al. J Neurochem, 2005 Jun. PMID 15935074
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. altered membrane NTPase activity is a biochemical hallmark of HPRT deficiency, but species and cell-type differences have to be considered
      Title: Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NTPase KAP family P-loop domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405941.2 → NP_001392870.1  NTPase KAP family P-loop domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149052
      UniProtKB/TrEMBL
      A0A1L1SVH6
      Related
      ENSMUSP00000151162.2, ENSMUST00000214205.2

    2. NM_027116.3 → NP_081392.1  NTPase KAP family P-loop domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149052
      Consensus CDS
      CCDS52059.1
      UniProtKB/TrEMBL
      H7BX48
      Related
      ENSMUSP00000147092.2, ENSMUST00000207576.2
      Conserved Domains (1) summary
      cl21455
      Location:251 → 544
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      19251404..19258982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540350.4 → XP_006540413.2  NTPase KAP family P-loop domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      PRK06549
      Location:274 → 331
      PRK06549; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
      cl38936
      Location:413 → 706
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_030242971.2 → XP_030098831.1  NTPase KAP family P-loop domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:263 → 556
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VF94.2 GenPept UniProtKB/Swiss-Prot:Q0VF94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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