Shisa7 shisa family member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Shisa7provided by MGI
Official Full Name: shisa family member 7provided by MGI
Primary source: MGI:MGI:3605641
See related: Ensembl:ENSMUSG00000053550 AllianceGenome:MGI:3605641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ckamp59
Summary: Enables GABA receptor binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including gamma-aminobutyric acid receptor clustering; positive regulation of long-term synaptic potentiation; and regulation of signaling receptor activity. Located in asymmetric, glutamatergic, excitatory synapse and postsynaptic density. Is active in glutamatergic synapse and postsynaptic specialization membrane. Is expressed in central nervous system; craniocervical region bone; dorsal root ganglion; rib; and tail mesenchyme. Orthologous to human SHISA7 (shisa family member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 32.2), whole brain E14.5 (RPKM 29.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 2.79 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (4828551..4847788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (4825551..4844866, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
Title: Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
data indicate that Shisa7 regulates GABAAR trafficking, function, and pharmacology and reveal a previously unknown molecular interaction that modulates benzodiazepine action in the brain
Title: Shisa7 is a GABA(A) receptor auxiliary subunit controlling benzodiazepine actions.
Thus, Shisa7 is a bona-fide AMPA receptor modulatory protein affecting channel kinetics of the receptors, necessary for synaptic hippocampal plasticity, and memory recall.
Title: The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory.
This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members 39, 52 and 59.
Title: Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:182516 (e-PCR)
- UniSTS:155384

AI553388 (e-PCR)
- UniSTS:164348

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GABA receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables GABA receptor binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables ionotropic glutamate receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of AMPA glutamate receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of AMPA glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic neurotransmitter receptor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic neurotransmitter receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
NOT part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
NOT located_in asymmetric, glutamatergic, excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in asymmetric, glutamatergic, excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine membrane	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: protein shisa-7

Names: GABA(A) receptor auxiliary subunit Shisa7; cysteine-knot AMPAR-modulating protein 59; cystine-knot AMPAR modulating protein of 59 kDa; shisa homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290291.1 → NP_001277220.1 protein shisa-7 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC162034, AK085127, CJ120465

Consensus CDS

CCDS71882.1

UniProtKB/Swiss-Prot

Q8C3Q5

UniProtKB/TrEMBL

A0A172Q401

Related

ENSMUSP00000112423.3, ENSMUST00000119433.4

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
NM_172737.4 → NP_766325.3 protein shisa-7 isoform 1 precursor

See identical proteins and their annotated locations for NP_766325.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC162034, AK085127, CF538627, CJ120465

UniProtKB/Swiss-Prot

A0A172Q401, A0A172Q418, Q3UMB3, Q8C3Q5

Related

ENSMUSP00000064886.6, ENSMUST00000066041.12

Conserved Domains (1) summary

pfam13908
Location:83 → 136

Shisa; Wnt and FGF inhibitory regulator

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

4828551..4847788 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242416.2 → XP_030098276.1 protein shisa-7 isoform X2

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator
XM_006539775.5 → XP_006539838.1 protein shisa-7 isoform X1

See identical proteins and their annotated locations for XP_006539838.1

UniProtKB/Swiss-Prot

A0A172Q401, A0A172Q418, Q3UMB3, Q8C3Q5

Conserved Domains (1) summary

pfam13908
Location:83 → 136

Shisa; Wnt and FGF inhibitory regulator
XM_030242417.2 → XP_030098277.1 protein shisa-7 isoform X3

Conserved Domains (1) summary

pfam13908
Location:83 → 142

Shisa; Wnt and FGF inhibitory regulator