Slc5a5 solute carrier family 5 (sodium iodide symporter), member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc5a5provided by MGI
Official Full Name: solute carrier family 5 (sodium iodide symporter), member 5provided by MGI
Primary source: MGI:MGI:2149330
See related: Ensembl:ENSMUSG00000000792 AllianceGenome:MGI:2149330
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NIS
Summary: Enables sodium:iodide symporter activity. Predicted to be involved in several processes, including cellular response to Thyroid stimulating hormone; cellular response to forskolin; and iodide transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in axial skeleton tail region; stomach; testis; and thyroid gland. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A5 (solute carrier family 5 member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in stomach adult (RPKM 130.4) and mammary gland adult (RPKM 64.6) See more
Orthologs: human all
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Genomic context

Location:: 8 B3.3; 8 34.36 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (71335529..71345429, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (70882885..70892785, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Report noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using Slc5a5 transgenic mice.
Title: Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene.
High potential of novel pseudodendritic polymers for tumor-specific NIS gene delivery after systemic application, opening the prospect of targeted NIS-mediated radionuclide therapy of nonthyroidal tumors even in metastatic disease.
Title: Targeted radioiodine therapy of neuroblastoma tumors following systemic nonviral delivery of the sodium iodide symporter gene.
The Na+/I- symporter mediates active iodide uptake in the intestine.
Title: The Na+/I- symporter mediates active iodide uptake in the intestine.
This study represents a promising first step in investigations of the potential use of a combination of the NIS gene and MDR1 shRNA as a new therapeutic strategy allowing RNA interference-based gene therapy.
Title: Combination therapy and noninvasive imaging with a dual therapeutic vector expressing MDR1 short hairpin RNA and a sodium iodide symporter.
Cloning of the mouse sodium iodide symporter.
Title: Cloning of the mouse sodium iodide symporter.
The high degree of homology in the 5'-flanking region between mouse and rat NIS suggests that mNIS and rNIS share similar mechanisms for transcriptional regulation in the thyroid.
Title: Cloning of the 5'-flanking region of mouse sodium/iodide symporter and identification of a thyroid-specific and TSH-responsive enhancer.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

General gene information

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Markers

Slc5a5 (e-PCR), detects polymorphism
- UniSTS:547351

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables iodide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sodium:iodide symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:iodide symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:iodide symporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to Thyroid stimulating hormone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in inorganic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in iodide transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in iodide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in iodide transport	IEA Inferred from Electronic Annotation more info
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/iodide cotransporter

Names: Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; sodium-iodide symporter; solute carrier family 5 member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053248.2 → NP_444478.2 sodium/iodide cotransporter

See identical proteins and their annotated locations for NP_444478.2

Status: VALIDATED

Source sequence(s)

AC019302, AK046718, BB645718, CD741961

Consensus CDS

CCDS22385.1

UniProtKB/Swiss-Prot

B2RPX6, Q99PN0

UniProtKB/TrEMBL

G3X8P5

Related

ENSMUSP00000000809.3, ENSMUST00000000809.3

Conserved Domains (1) summary

cd11503
Location:15 → 549

SLC5sbd_NIS; Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

71335529..71345429 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509537.4 → XP_006509600.1 sodium/iodide cotransporter isoform X1

UniProtKB/Swiss-Prot

B2RPX6, Q99PN0

Conserved Domains (1) summary

cl00456
Location:15 → 527

SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain