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    A4gnt alpha-1,4-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 333424, updated on 27-Nov-2024

    Summary

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    Official Symbol
    A4gntprovided by MGI
    Official Full Name
    alpha-1,4-N-acetylglucosaminyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2143261
    See related
    Ensembl:ENSMUSG00000037953 AllianceGenome:MGI:2143261
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm798; Alpha4gnt
    Summary
    This gene encodes a protein from the glycosyltransferase 32 family. The encoded enzyme catalyzes the transfer of N-acetylglucosamine to alpha-1,4-linked beta-galactose residues. This enzyme is required for type III mucin synthesis and it is largely associated with the Golgi apparatus membrane. The encoded protein appears to be expressed in adenocarcinoma cells of pancreatic, biliary tract and gastric cancers.[provided by RefSeq, Jan 2010]
    Expression
    Biased expression in stomach adult (RPKM 13.0), duodenum adult (RPKM 7.6) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See A4gnt in Genome Data Viewer
    Location:
    9 E3.3; 9 51.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99473233..99504420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99591179..99622367)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25026 Neighboring gene NME/NM23 family member 9 Neighboring gene armadillo repeat containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E6796 Neighboring gene debranching RNA lariats 1 Neighboring gene DAZ interacting protein 1-like Neighboring gene claudin 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of orally administered Euglena gracilis and its reserve polysaccharide, paramylon, on gastric dysplasia in A4gnt knockout mice. Iida M, et al. Sci Rep, 2021 Jul 1. PMID 34210998, Free PMC Article
    2. Analysis of A4gnt Knockout Mice Reveals an Essential Role for Gastric Sulfomucins in Preventing Gastritis Cystica Profunda. Kawakubo M, et al. J Histochem Cytochem, 2019 Oct. PMID 31246144, Free PMC Article
    3. Essential role of gastric gland mucin in preventing gastric cancer in mice. Karasawa F, et al. J Clin Invest, 2012 Mar. PMID 22307328, Free PMC Article
    4. Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk. Zheng Z, et al. Helicobacter, 2009 Oct. PMID 19751437, Free PMC Article
    5. Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin. Nakayama J, et al. Proc Natl Acad Sci U S A, 1999 Aug 3. PMID 10430883, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A4gnt(-/-) mice show complete lack of alphaGlcNAc expression in gastric gland mucin
      Title: Essential role of gastric gland mucin in preventing gastric cancer in mice.
    2. This publication contains functional information for the human homolog of mouse A4gnt.
      Title: Expression cloning of a human alpha1, 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1-->4Galbeta-->R, a glycan specifically expressed in the gastric gland mucous cell-type mucin.
    3. This publication contains functional information for the human homolog of mouse A4gnt.
      Title: Genetic variation in a4GnT in relation to Helicobacter pylori serology and gastric cancer risk.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylglucosaminyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein O-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,4-N-acetylglucosaminyltransferase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077424.2 → NP_001070892.1  alpha-1,4-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_001070892.1

      Status: REVIEWED

      Source sequence(s)
      AC157949, AK136425
      Consensus CDS
      CCDS40740.1
      UniProtKB/Swiss-Prot
      Q14BT6
      Related
      ENSMUSP00000045629.8, ENSMUST00000042553.8
      Conserved Domains (2) summary
      pfam04488
      Location:65 → 183
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:202 → 324
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      99473233..99504420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511246.5 → XP_006511309.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006511309.1

      UniProtKB/Swiss-Prot
      Q14BT6
      Conserved Domains (2) summary
      pfam04488
      Location:65 → 183
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:202 → 324
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    2. XM_006511244.5 → XP_006511307.3  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

      Conserved Domains (2) summary
      pfam04488
      Location:130 → 248
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:267 → 389
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14BT6.1 GenPept UniProtKB/Swiss-Prot:Q14BT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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