Cep68 centrosomal protein 68 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cep68provided by MGI
Official Full Name: centrosomal protein 68provided by MGI
Primary source: MGI:MGI:2667663
See related: Ensembl:ENSMUSG00000044066 AllianceGenome:MGI:2667663
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kiaa0582; 6030463E10Rik
Summary: Predicted to enable protein domain specific binding activity and protein kinase binding activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to be located in several cellular components, including centriolar satellite; cytosol; and nucleoplasm. Is expressed in several structures, including ganglia; incisor; submandibular gland primordium; telencephalon ventricular layer; and thymus primordium. Orthologous to human CEP68 (centrosomal protein 68). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in liver E18 (RPKM 13.8), heart adult (RPKM 11.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.1; 11 12.92 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (20177037..20199424, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (20227037..20249424, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

WI-13176 (e-PCR)
- UniSTS:21297

AI481761 (e-PCR)
- UniSTS:160072

D11Hjk3 (e-PCR), detects polymorphism
- UniSTS:141747

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in centriole-centriole cohesion	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to organelle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centrosomal protein of 68 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172260.3 → NP_758464.2 centrosomal protein of 68 kDa

See identical proteins and their annotated locations for NP_758464.2

Status: PROVISIONAL

Source sequence(s)

AK140820

Consensus CDS

CCDS24456.1

UniProtKB/Swiss-Prot

Q3US49, Q5SW85, Q8C0D9, Q8R2V0

UniProtKB/TrEMBL

Q3ULV4

Related

ENSMUSP00000054943.8, ENSMUST00000050611.14

Conserved Domains (1) summary

cl02488
Location:605 → 700

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...