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    Zfp488 zinc finger protein 488 [ Mus musculus (house mouse) ]

    Gene ID: 382867, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp488provided by MGI
    Official Full Name
    zinc finger protein 488provided by MGI
    Primary source
    MGI:MGI:2686052
    See related
    Ensembl:ENSMUSG00000044519 AllianceGenome:MGI:2686052
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1206; Znf488
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of myelination and positive regulation of oligodendrocyte differentiation. Acts upstream of or within negative regulation of DNA-templated transcription and oligodendrocyte development. Located in nucleus. Is expressed in central nervous system and optic nerve. Orthologous to human ZNF488 (zinc finger protein 488). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Zfp488 in Genome Data Viewer
    Location:
    14 B; 14 20.8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33689023..33700986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33967070..33979034, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 2 Neighboring gene retinol binding protein 3, interstitial Neighboring gene predicted gene, 30083 Neighboring gene STARR-seq mESC enhancer starr_36360 Neighboring gene predicted gene 5460 Neighboring gene RIKEN cDNA A630023A22 gene Neighboring gene anthrax toxin receptor-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp488 promotes oligodendrocyte differentiation of neural progenitor cells in adult mice after demyelination. Soundarapandian MM, et al. Sci Rep, 2011. PMID 22355521, Free PMC Article
    2. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation. Schmidt AL, et al. Glia, 2024 Jul. PMID 38546197
    3. An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation. Wang SZ, et al. Development, 2006 Sep. PMID 16908628
    4. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation.
      Title: The myelination-associated G protein-coupled receptor 37 is regulated by Zfp488, Nkx2.2, and Sox10 during oligodendrocyte differentiation.
    2. Zfp488 functions as an oligodendrocyte-specific transcription co-regulator important for oligodendrocyte maturation
      Title: An oligodendrocyte-specific zinc-finger transcription regulator cooperates with Olig2 to promote oligodendrocyte differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oligodendrocyte development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within oligodendrocyte development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 488
    NP_001013799.2
    XP_006519261.1
    XP_036014633.1
    XP_036014634.1
    XP_036014635.1
    XP_036014636.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013777.3 → NP_001013799.2  zinc finger protein 488

      See identical proteins and their annotated locations for NP_001013799.2

      Status: VALIDATED

      Source sequence(s)
      AC166828
      Consensus CDS
      CCDS26930.2
      UniProtKB/Swiss-Prot
      Q5HZG9
      Related
      ENSMUSP00000132436.2, ENSMUST00000166737.2
      Conserved Domains (1) summary
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      33689023..33700986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158743.1 → XP_036014636.1  zinc finger protein 488 isoform X2

      Conserved Domains (1) summary
      sd00017
      Location:312 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006519198.5 → XP_006519261.1  zinc finger protein 488 isoform X3

      See identical proteins and their annotated locations for XP_006519261.1

      UniProtKB/Swiss-Prot
      Q5HZG9
      Conserved Domains (1) summary
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036158741.1 → XP_036014634.1  zinc finger protein 488 isoform X1

      Conserved Domains (1) summary
      sd00017
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_036158740.1 → XP_036014633.1  zinc finger protein 488 isoform X1

      Conserved Domains (1) summary
      sd00017
      Location:318 → 338
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036158742.1 → XP_036014635.1  zinc finger protein 488 isoform X2

      Conserved Domains (1) summary
      sd00017
      Location:312 → 332
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZG9.2 GenPept UniProtKB/Swiss-Prot:Q5HZG9

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