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    Svs3a seminal vesicle secretory protein 3A [ Mus musculus (house mouse) ]

    Gene ID: 64335, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Svs3aprovided by MGI
    Official Full Name
    seminal vesicle secretory protein 3Aprovided by MGI
    Primary source
    MGI:MGI:1927635
    See related
    Ensembl:ENSMUSG00000017003 AllianceGenome:MGI:1927635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Svp3; Svs3; Semg2; Svp-3; 9530026M05Rik
    Summary
    Predicted to enable protease binding activity and zinc ion binding activity. Acts upstream of or within mating plug formation. Located in extracellular region. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Svs3a in Genome Data Viewer
    Location:
    2 H3; 2 85.07 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164131187..164133420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164289267..164291500)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene seminal vesicle secretory protein 3B Neighboring gene seminal vesicle secretory protein 4 Neighboring gene seminal vesicle secretory protein 6 Neighboring gene seminal vesicle secretory protein 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42. Lin HJ, et al. Biochem Biophys Res Commun, 2005 Jan 14. PMID 15582586
    2. Localization of the transglutaminase cross-linking site in SVS III, a novel glycoprotein secreted from mouse seminal vesicle. Lin HJ, et al. J Biol Chem, 2002 Feb 1. PMID 11723121
    3. Syp-3, a third polymorphic locus for mouse seminal vesicle proteins. Moutier R, et al. Biochem Genet, 1983 Aug. PMID 6626148
    4. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. Ulvsbäck M, et al. J Biol Chem, 1992 Sep 5. PMID 1517240
    5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Report the gene duplication of SVS III in both mouse and rat.
      Title: Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mating plug formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm capacitation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    seminal vesicle secretory protein 3A
    Names
    SVS III
    semenogelin II
    seminal vesicle protein 3
    seminal vesicle secretion 3 alpha
    seminal vesicle secretion 3A
    seminal vesicle secretory protein III

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311114.1 → NP_001298043.1  seminal vesicle secretory protein 3A isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK020575, AL590429
      Consensus CDS
      CCDS79860.1
      UniProtKB/Swiss-Prot
      F2Z472
      Related
      ENSMUSP00000104995.2, ENSMUST00000109370.2

    2. NM_021363.2 → NP_067338.2  seminal vesicle secretory protein 3A isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK020575, BC131996, BY722061, DV048837
      Consensus CDS
      CCDS17030.1
      UniProtKB/Swiss-Prot
      F2Z467, F2Z472, Q8VI13, Q9JKD2
      Related
      ENSMUSP00000017147.8, ENSMUST00000017147.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164131187..164133420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F2Z472.1 GenPept UniProtKB/Swiss-Prot:F2Z472

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