Ccl5 C-C motif chemokine ligand 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccl5provided by MGI
Official Full Name: C-C motif chemokine ligand 5provided by MGI
Primary source: MGI:MGI:98262
See related: Ensembl:ENSMUSG00000035042 AllianceGenome:MGI:98262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SISd; Scya5; RANTES; TCP228; MuRantes
Summary: Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in small intestine adult (RPKM 266.1), mammary gland adult (RPKM 266.0) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 50.66 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (83416604..83421344, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (83525778..83530518, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
Title: The myokine CCL5 recruits subcutaneous preadipocytes and promotes intramuscular fat deposition in obese mice.
Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.
Title: Role of the CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, Vascular Dysfunction, and End-Organ Damage.
CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke.
Title: CCL5 mediated astrocyte-T cell interaction disrupts blood-brain barrier in mice after hemorrhagic stroke.
CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.
Title: CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.
C-C Motif Chemokine Ligand 5 (CCL5) Promotes Irradiation-Evoked Osteoclastogenesis.
Title: C-C Motif Chemokine Ligand 5 (CCL5) Promotes Irradiation-Evoked Osteoclastogenesis.
Identification of C-C motif chemokine ligand 5 as a heat-dependent myokine.
Title: Identification of C-C motif chemokine ligand 5 as a heat-dependent myokine.
Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing.
Title: Single cell transcriptomics of bone marrow derived macrophages reveals Ccl5 as a biomarker of direct IFNAR-independent responses to DNA sensing.
HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism.
Title: HSV-1 infection-induced herpetic neuralgia involves a CCL5/CCR5-mediated inflammation mechanism.
Upregulation of CCL5/RANTES Gene Expression in the Diaphragm of Mice with Cholestatic Liver Disease.
Title: Upregulation of CCL5/RANTES Gene Expression in the Diaphragm of Mice with Cholestatic Liver Disease.
CCL5/CCR5-mediated peripheral inflammation exacerbates blood-brain barrier disruption after intracerebral hemorrhage in mice.
Title: CCL5/CCR5-mediated peripheral inflammation exacerbates blood‒brain barrier disruption after intracerebral hemorrhage in mice.

Submit: New GeneRIF Correction See all GeneRIFs (148)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ccl5 (e-PCR), detects polymorphism
- UniSTS:470612

Ccl5 (e-PCR), detects polymorphism
- UniSTS:530818

Ccl5 (e-PCR), detects polymorphism
- UniSTS:265645

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CCR1 chemokine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables CCR1 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CCR5 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CCR5 chemokine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables chemoattractant activity	IEA Inferred from Electronic Annotation more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine activity	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine receptor antagonist activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor antagonist activity	ISS Inferred from Sequence or Structural Similarity more info
enables chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activator activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activator activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables receptor signaling protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 1 cell diapedesis	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase D activity	ISO Inferred from Sequence Orthology more info
involved_in activation of phospholipase D activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to fibroblast growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in cellular response to virus	IEA Inferred from Electronic Annotation more info
involved_in chemokine (C-C motif) ligand 5 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in chemokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in eosinophil chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in eosinophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in eosinophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation by host of viral transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation by host of viral transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion mediated by integrin	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 2 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of defense response to virus by host	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of homotypic cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor signaling pathway via STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in pseudopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to toxic substance	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-C motif chemokine 5

Names: SIS-delta; T-cell-specific protein RANTES; chemokine (C-C motif) ligand 5; small-inducible cytokine A5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013653.3 → NP_038681.2 C-C motif chemokine 5 precursor

See identical proteins and their annotated locations for NP_038681.2

Status: VALIDATED

Source sequence(s)

AK003101, BE333205

Consensus CDS

CCDS36254.1

UniProtKB/Swiss-Prot

P30882

UniProtKB/TrEMBL

Q5XZF2

Related

ENSMUSP00000039600.3, ENSMUST00000035938.3

Conserved Domains (1) summary

cd00272
Location:33 → 89

Chemokine_CC; Chemokine_CC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; some members (e.g. ...