Fbxo2 F-box protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxo2provided by MGI
Official Full Name: F-box protein 2provided by MGI
Primary source: MGI:MGI:2446216
See related: Ensembl:ENSMUSG00000041556 AllianceGenome:MGI:2446216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FBG1; FBX2; Fbs1; Fbs2; NFB42; Prpl4
Summary: Enables amyloid-beta binding activity; carbohydrate binding activity; and denatured protein binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; glycoprotein catabolic process; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within ERAD pathway; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol and dendritic spine. Part of SCF ubiquitin ligase complex. Is active in glutamatergic synapse. Is expressed in brain; testis; and vestibulo-cochlear ganglion. Orthologous to human FBXO2 (F-box protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 35.4), cortex adult (RPKM 30.5) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 78.68 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148244605..148250874)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148160198..148166420)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway.
Title: Sleeve Gastrectomy Improves Hepatic Glucose Metabolism by Downregulating FBXO2 and Activating the PI3K-AKT Pathway.
F-box only protein 2 (FBXO2), a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex, was upregulated in livers of obese mice. Furthermore, using a protein purification approach combined with high-performance liquid chromatography/tandem mass spectrometry, we carried out a system-wide screening of FBXO2 substrates, in which the insulin receptor (IR) was identified as a substrate
Title: Aberrant Expression of FBXO2 Disrupts Glucose Homeostasis Through Ubiquitin-Mediated Degradation of Insulin Receptor in Obese Mice.
FBG1 degrades A1AT-Z through a Beclin1-dependent arm of autophagy.
Title: FBG1 Is the Final Arbitrator of A1AT-Z Degradation.
The results of this study suggested that Fbxo2 controls the abundance and localization of specific NMDAR subunits in the brain and may influence synapse formation and maintenance.
Title: Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.
these results suggest that Fbxo2 regulates APP levels and processing in the brain and may play a role in modulating Alzheimer disease pathogenesis.
Title: F-box only protein 2 (Fbxo2) regulates amyloid precursor protein levels and processing.
our studies support a non-essential role for FBG1 on the degradation of torsinA and uncover a novel link of FBG1 to the autophagy pathway.
Title: The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy.
Our findings demonstrate that components of protein quality control are essential for inner ear homeostasis and implicate Fbx2 and Skp1 as potential genetic modifiers in age-related hearing loss.
Title: Selective cochlear degeneration in mice lacking the F-box protein, Fbx2, a glycoprotein-specific ubiquitin ligase subunit.
When expressed in hippocampal neurons, the Fbx2 dominant-negative mutant augmented NR1 subunit levels and NMDA receptor-mediated currents in an activity-dependent fashion
Title: Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitination.
Fbs1 assists clearance of aberrant glycoproteins in neuronal cells by suppressing aggregates formation, independent of ubiquitin ligase activity, and thus functions as a unique chaperone for those proteins.
Title: A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables denatured protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ERAD pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycoprotein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycoprotein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extrinsic component of postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in extrinsic component of postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box only protein 2

Names: prion protein ligand 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419436.1 → NP_001406365.1 F-box only protein 2

Status: VALIDATED

Source sequence(s)

AL606929

UniProtKB/Swiss-Prot

Q80UW2, Q8R0D2

UniProtKB/TrEMBL

Q3USR5
NM_001419437.1 → NP_001406366.1 F-box only protein 2

Status: VALIDATED

Source sequence(s)

AL606929

UniProtKB/Swiss-Prot

Q80UW2, Q8R0D2

UniProtKB/TrEMBL

Q3USR5
NM_176848.2 → NP_789818.1 F-box only protein 2

See identical proteins and their annotated locations for NP_789818.1

Status: VALIDATED

Source sequence(s)

AL606929

Consensus CDS

CCDS18935.1

UniProtKB/Swiss-Prot

Q80UW2, Q8R0D2

UniProtKB/TrEMBL

Q3USR5

Related

ENSMUSP00000037377.9, ENSMUST00000047951.9

Conserved Domains (2) summary

pfam00646
Location:61 → 96

F-box; F-box domain

pfam04300
Location:118 → 293

FBA; F-box associated region