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    Slc6a20a solute carrier family 6 (neurotransmitter transporter), member 20A [ Mus musculus (house mouse) ]

    Gene ID: 102680, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc6a20aprovided by MGI
    Official Full Name
    solute carrier family 6 (neurotransmitter transporter), member 20Aprovided by MGI
    Primary source
    MGI:MGI:2143217
    See related
    Ensembl:ENSMUSG00000036814 AllianceGenome:MGI:2143217
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xt3s1; Xtrp3s1; A730081N20Rik
    Summary
    Enables L-proline transmembrane transporter activity and proline:sodium symporter activity. Involved in L-proline import across plasma membrane and glycine import across plasma membrane. Acts upstream of or within amino-acid betaine transport and proline transmembrane transport. Located in apical plasma membrane. Is expressed in brain; early conceptus; metanephros; and secondary oocyte. Orthologous to human SLC6A20 (solute carrier family 6 member 20). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in duodenum adult (RPKM 115.2), small intestine adult (RPKM 65.2) and 4 other tissues See more
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    Genomic context

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    See Slc6a20a in Genome Data Viewer
    Location:
    9 F4; 9 74.26 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (123465972..123507897, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (123636907..123678832, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SAC1 suppressor of actin mutations 1-like (yeast) Neighboring gene solute carrier family 6 (neurotransmitter transporter), member 20B Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_25570 Neighboring gene leucine zipper transcription factor-like 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626087-123626387 Neighboring gene STARR-positive B cell enhancer mm9_chr9:123626696-123626997

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes. Kim J, et al. Front Mol Neurosci, 2022. PMID 35321029, Free PMC Article
    2. Targeted disruption of Rab1a causes early embryonic lethality. Wu Y, et al. Int J Mol Med, 2022 Apr. PMID 35137917, Free PMC Article
    3. Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance. Do TT, et al. Am J Physiol Endocrinol Metab, 2014 Mar. PMID 24425764
    4. SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. Bae M, et al. EMBO Mol Med, 2021 Feb 5. PMID 33428810, Free PMC Article
    5. Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter. Kowalczuk S, et al. Biochem J, 2005 Mar 15. PMID 15689184, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that a high-fat diet induces expression of two amino acid transporters (Slc6a20a, Slc36a1) in intestinal mucosa pointing to a specific and adaptive absorption of some amino acids in high-fat diet-induced obesity and glucose intolerance.
      Title: Disturbed intestinal nitrogen homeostasis in a mouse model of high-fat diet-induced obesity and glucose intolerance.
    2. We assessed two candidates for the betaine/proline transporter: SIT1 (IMINO; encoded by Slc6a20a) and PROT (Slc6a7). mRNA from both genes was present in eggs and 1-cell embryos.
      Title: SIT1 is a betaine/proline transporter that is activated in mouse eggs after fertilization and functions until the 2-cell stage.
    3. molecular cloning of two mouse homologues corresponding to the single human SLC6A20 gene: these have been named XT3 and XT3s1 [Xt3s1]
      Title: Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-proline transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-proline transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-proline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino-acid betaine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neutral L-amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neutral L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables solute:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables solute:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-proline import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within amino-acid betaine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in amino-acid betaine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proline import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proline transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sodium- and chloride-dependent transporter XTRP3A
    Names
    IMINO-B
    X transporter protein 3 similar 1
    solute carrier family 6 member 20A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139142.2 → NP_631881.1  sodium- and chloride-dependent transporter XTRP3A

      See identical proteins and their annotated locations for NP_631881.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118933
      Consensus CDS
      CCDS40817.1
      UniProtKB/Swiss-Prot
      Q3USE2, Q8VDB9
      UniProtKB/TrEMBL
      E9Q0H0
      Related
      ENSMUSP00000047690.7, ENSMUST00000040960.13
      Conserved Domains (1) summary
      cl00456
      Location:2 → 577
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      123465972..123507897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDB9.1 GenPept UniProtKB/Swiss-Prot:Q8VDB9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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