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    Slc7a4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 224022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a4provided by MGI
    Official Full Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 4provided by MGI
    Primary source
    MGI:MGI:2146512
    See related
    Ensembl:ENSMUSG00000022756 AllianceGenome:MGI:2146512
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable amino acid transmembrane transporter activity. Predicted to be involved in amino acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; heart; nervous system; nose; and testis. Orthologous to human SLC7A4 (solute carrier family 7 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 44.4), ovary adult (RPKM 14.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc7a4 in Genome Data Viewer
    Location:
    16 A3; 16 10.89 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17389882..17394619, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17572018..17576890, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 74B Neighboring gene STARR-positive B cell enhancer ABC_E10890 Neighboring gene STARR-seq mESC enhancer starr_40257 Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 6 Neighboring gene STARR-seq mESC enhancer starr_40258 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17619324-17619507 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene STARR-seq mESC enhancer starr_40259 Neighboring gene coiled-coil domain containing 74A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
    2. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
    3. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. O'Shaughnessy PJ, et al. Endocrinology, 2007 Jun. PMID 17332066
    4. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27672

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carboxylic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cationic amino acid transporter 4
    Names
    CAT-4
    CAT4
    solute carrier family 7 member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359891.2 → NP_001346820.1  cationic amino acid transporter 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC115733
      Consensus CDS
      CCDS28008.1
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4
      Conserved Domains (1) summary
      TIGR00906
      Location:14 → 592
      2A0303; cationic amino acid transport permease

    2. NM_001359892.2 → NP_001346821.1  cationic amino acid transporter 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115733
      Conserved Domains (1) summary
      cl26159
      Location:79 → 657
      AA_permease_2; Amino acid permease

    3. NM_001359893.2 → NP_001346822.1  cationic amino acid transporter 4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC115733
      Consensus CDS
      CCDS28008.1
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4
      Conserved Domains (1) summary
      TIGR00906
      Location:14 → 592
      2A0303; cationic amino acid transport permease

    4. NM_001416939.1 → NP_001403868.1  cationic amino acid transporter 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4

    5. NM_001416940.1 → NP_001403869.1  cationic amino acid transporter 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4

    6. NM_001416941.1 → NP_001403870.1  cationic amino acid transporter 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4

    7. NM_001416942.1 → NP_001403871.1  cationic amino acid transporter 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115733
      Related
      ENSMUSP00000156166.2, ENSMUST00000232226.2

    8. NM_001416943.1 → NP_001403872.1  cationic amino acid transporter 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC115733

    9. NM_001416944.1 → NP_001403873.1  cationic amino acid transporter 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/TrEMBL
      A0A338P754

    10. NM_001416945.1 → NP_001403874.1  cationic amino acid transporter 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/TrEMBL
      A0A338P754
      Related
      ENSMUSP00000156098.2, ENSMUST00000232385.2

    11. NM_001416946.1 → NP_001403875.1  cationic amino acid transporter 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC115733
      UniProtKB/TrEMBL
      A0A338P754
      Related
      ENSMUSP00000156027.2, ENSMUST00000231615.2

    12. NM_001416947.1 → NP_001403876.1  cationic amino acid transporter 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC115733

    13. NM_144852.3 → NP_659101.2  cationic amino acid transporter 4 isoform 2

      See identical proteins and their annotated locations for NP_659101.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK043772
      Consensus CDS
      CCDS28008.1
      UniProtKB/Swiss-Prot
      Q8BLQ7
      UniProtKB/TrEMBL
      Q8BML4
      Related
      ENSMUSP00000127280.2, ENSMUST00000172164.10
      Conserved Domains (1) summary
      TIGR00906
      Location:14 → 592
      2A0303; cationic amino acid transport permease

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17389882..17394619 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_875780.4 RNA Sequence

    2. XR_875779.4 RNA Sequence

    3. XR_384551.5 RNA Sequence

    4. XR_384549.5 RNA Sequence

      Related
      ENSMUST00000232429.2

    5. XR_384548.4 RNA Sequence

    6. XR_004939182.1 RNA Sequence

    7. XR_875781.3 RNA Sequence

    8. XR_384553.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BLQ7.1 GenPept UniProtKB/Swiss-Prot:Q8BLQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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