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    Myadm myeloid-associated differentiation marker [ Mus musculus (house mouse) ]

    Gene ID: 50918, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myadmprovided by MGI
    Official Full Name
    myeloid-associated differentiation markerprovided by MGI
    Primary source
    MGI:MGI:1355332
    See related
    Ensembl:ENSMUSG00000068566 AllianceGenome:MGI:1355332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D7Wsu62e
    Summary
    Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; negative regulation of protein kinase C signaling; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cortical actin cytoskeleton; membrane raft; and ruffle. Predicted to be active in cell-cell junction and plasma membrane. Is expressed in several structures, including immune system; intestine smooth muscle circular layer; limb; liver; and lung. Orthologous to human MYADM (myeloid associated differentiation marker). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 144.9), subcutaneous fat pad adult (RPKM 132.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myadm in Genome Data Viewer
    Location:
    7 A1; 7 1.92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3337563..3347871)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3289038..3299355)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17893 Neighboring gene olfactory receptor GA_x5J8B7W3939-136239-135295 Neighboring gene STARR-positive B cell enhancer ABC_E10422 Neighboring gene acidic ribosomal phosphoprotein P0 pseudogene Neighboring gene protein kinase C, gamma Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene calcium channel, voltage-dependent, gamma subunit 7 Neighboring gene STARR-seq mESC enhancer starr_17900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization. Dannaeus K, et al. Mol Biol Rep, 2005 Sep. PMID 16172915
    2. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity. Dy ABC, et al. Sci Rep, 2021 Dec 3. PMID 34862427, Free PMC Article
    3. Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. Pettersson M, et al. J Leukoc Biol, 2000 Mar. PMID 10733104
    4. Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability. Wang J, et al. Hypertension, 2024 Aug. PMID 38832511
    5. Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Horie K, et al. Mol Cell Biol, 2003 Dec. PMID 14645530, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
      Title: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular Remodeling by Regulating Myadm Transcript Stability.
    2. Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
      Title: Myeloid-associated differentiation marker is a novel SP-A-associated transmembrane protein whose expression on airway epithelial cells correlates with asthma severity.
    3. Functional analysis of the promotor region of the MYADM gene.
      Title: Characterization of the mouse myeloid-associated differentiation marker (MYADM) gene: promoter analysis and protein localization.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation
    • Transposon induced (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in establishment of endothelial barrier IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of endothelial barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane raft organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane raft organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of heterotypic cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    myeloid-associated differentiation marker
    Names
    myeloid up-regulated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001093764.1 → NP_001087233.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001087233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI842980, AK052258, BY163724, CJ156102, CK782239
      Consensus CDS
      CCDS51964.1
      UniProtKB/Swiss-Prot
      O35682, Q8BGS9, Q8BPS8
      UniProtKB/TrEMBL
      Q0VE46
      Related
      ENSMUSP00000144984.2, ENSMUST00000203328.4
      Conserved Domains (1) summary
      pfam01284
      Location:39 → 146
      MARVEL; Membrane-associating domain

    2. NM_001093765.1 → NP_001087234.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001087234.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI842980, AK052258, BY252968, BY767460
      Consensus CDS
      CCDS51964.1
      UniProtKB/Swiss-Prot
      O35682, Q8BGS9, Q8BPS8
      UniProtKB/TrEMBL
      Q0VE46
      Related
      ENSMUSP00000145120.2, ENSMUST00000203566.3
      Conserved Domains (1) summary
      pfam01284
      Location:39 → 146
      MARVEL; Membrane-associating domain

    3. NM_001093766.1 → NP_001087235.1  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_001087235.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI842980, AK052258, CF166357
      Consensus CDS
      CCDS51964.1
      UniProtKB/Swiss-Prot
      O35682, Q8BGS9, Q8BPS8
      UniProtKB/TrEMBL
      Q0VE46
      Related
      ENSMUSP00000131318.2, ENSMUST00000164553.8
      Conserved Domains (1) summary
      pfam01284
      Location:39 → 146
      MARVEL; Membrane-associating domain

    4. NM_016969.2 → NP_058665.2  myeloid-associated differentiation marker

      See identical proteins and their annotated locations for NP_058665.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AI842980, AK052258, AK089538, BY060170
      Consensus CDS
      CCDS51964.1
      UniProtKB/Swiss-Prot
      O35682, Q8BGS9, Q8BPS8
      UniProtKB/TrEMBL
      Q0VE46
      Related
      ENSMUSP00000094505.6, ENSMUST00000096744.8
      Conserved Domains (1) summary
      pfam01284
      Location:39 → 146
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3337563..3347871
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540171.5 → XP_006540234.1  myeloid-associated differentiation marker isoform X1

      See identical proteins and their annotated locations for XP_006540234.1

      UniProtKB/Swiss-Prot
      O35682, Q8BGS9, Q8BPS8
      UniProtKB/TrEMBL
      Q0VE46
      Conserved Domains (1) summary
      pfam01284
      Location:39 → 146
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35682.2 GenPept UniProtKB/Swiss-Prot:O35682

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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