Calm4 calmodulin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Calm4provided by MGI
Official Full Name: calmodulin 4provided by MGI
Primary source: MGI:MGI:1931464
See related: Ensembl:ENSMUSG00000033765 AllianceGenome:MGI:1931464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DD112; Scarf; 2310037J09Rik
Summary: Enables calcium ion binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; bladder; rib; skin; and thymus. Orthologous to human CALML5 (calmodulin like 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 13 A1; 13 2.15 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (3887757..3888671)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (3837757..3838671)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb.
Title: Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb.
Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Title: Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.
Calm4 is dispensable for epidermal barrier formation, maintenance and repair
Title: Calmodulin 4 is dispensable for epidermal barrier formation and wound healing in mice.
expression pattern for Scarf and Scarf2 transcripts and proteins in the developing mouse epidermis.
Title: The temporal and spatial expression of the novel Ca++-binding proteins, Scarf and Scarf2, during development and epidermal differentiation.
Scarf plays a critical role as a Ca2+ sensor, potentially regulating the function of its binding target proteins in a Ca2+-dependent manner in the process of restoration of epidermal Ca2+ gradient as well as during epidermal barrier formation
Title: Role of Scarf and its binding target proteins in epidermal calcium homeostasis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

AI649108 (e-PCR)
- UniSTS:180493

Calm4 (e-PCR), detects polymorphism
- UniSTS:547402

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: calmodulin-4

Names: calcium binding gene, DD112; calcium-binding protein Dd112; skin calmodulin-related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020036.4 → NP_064420.2 calmodulin-4

See identical proteins and their annotated locations for NP_064420.2

Status: VALIDATED

Source sequence(s)

AI131917, AK009956

Consensus CDS

CCDS26215.1

UniProtKB/Swiss-Prot

Q9CR31, Q9D1E9, Q9JM83

Related

ENSMUSP00000041636.5, ENSMUST00000042219.6

Conserved Domains (2) summary

PTZ00184
Location:1 → 148

PTZ00184; calmodulin; Provisional

cd00051
Location:12 → 73

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...