Lrrc26 leucine rich repeat containing 26 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrrc26provided by MGI
Official Full Name: leucine rich repeat containing 26provided by MGI
Primary source: MGI:MGI:2385129
See related: Ensembl:ENSMUSG00000026961 AllianceGenome:MGI:2385129
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in positive regulation of voltage-gated potassium channel activity and potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC26 (leucine rich repeat containing 26). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 104.2), stomach adult (RPKM 80.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.14 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25179923..25181205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25289911..25291193)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.
Title: Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice.
Roles of LRRC26 as an auxiliary gamma1-subunit of large-conductance Ca(2+)-activated K(+) channels in bronchial smooth muscle cells, is reported.
Title: Roles of LRRC26 as an auxiliary γ1-subunit of large-conductance Ca(2+)-activated K(+) channels in bronchial smooth muscle cells.
LRRC26-containing BK channels are competent to contribute to resting K(+) efflux at normal cell membrane potentials with resting cytosolic Ca(2+) concentrations and likely play a critical physiological role in supporting normal secretory function in all secretory epithelial cells.
Title: Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables potassium channel activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables potassium channel activator activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables potassium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated potassium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 26

Names: BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146117.2 → NP_666229.1 leucine-rich repeat-containing protein 26 precursor

See identical proteins and their annotated locations for NP_666229.1

Status: VALIDATED

Source sequence(s)

AL732309

Consensus CDS

CCDS15763.1

UniProtKB/Swiss-Prot

Q3UUY1, Q91W20

Related

ENSMUSP00000028337.7, ENSMUST00000028337.7

Conserved Domains (5) summary

smart00370
Location:118 → 141

LRR; Leucine-rich repeats, outliers

sd00033
Location:73 → 96

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:169 → 204

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:72 → 131

LRR_8; Leucine rich repeat

cl15307
Location:201 → 244

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain