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    Zbtb38 zinc finger and BTB domain containing 38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315936, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb38provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 38provided by RGD
    Primary source
    RGD:1310136
    See related
    EnsemblRapid:ENSRNOG00000012386 AllianceGenome:RGD:1310136
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310136
    Summary
    Enables DNA-binding transcription factor activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human ZBTB38 (zinc finger and BTB domain containing 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 63.6), Heart (RPKM 62.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb38 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (106124181..106231215, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97284617..97288518, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104566999..104694890, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 78 Neighboring gene uncharacterized LOC120094237 Neighboring gene RAS p21 protein activator 2 Neighboring gene peptidyl-prolyl cis-trans isomerase D pseudogene Neighboring gene uncharacterized LOC100909637 Neighboring gene uncharacterized LOC134480088 Neighboring gene 2-phosphoxylose phosphatase 1 Neighboring gene uncharacterized LOC120094379

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons. Kiefer H, et al. Mol Cell Biol, 2005 Mar. PMID 15713629, Free PMC Article
    2. The RBBP6/ZBTB38/MCM10 axis regulates DNA replication and common fragile site stability. Miotto B, et al. Cell Rep, 2014 Apr 24. PMID 24726359
    3. A family of human zinc finger proteins that bind methylated DNA and repress transcription. Filion GJ, et al. Mol Cell Biol, 2006 Jan. PMID 16354688, Free PMC Article
    4. On how mammalian transcription factors recognize methylated DNA. Buck-Koehntop BA, et al. Epigenetics, 2013 Feb. PMID 23324617, Free PMC Article
    5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZENON is involved in the maintenance of panneuronal features and/or in the survival of mature neurons.
      Title: ZENON, a novel POZ Kruppel-like DNA binding protein associated with differentiation and/or survival of late postmitotic neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 38
    Names
    zenon
    zinc finger protein expressed in neurons
    zinc finger transcription factor Kaiso

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012471.2 → NP_001012489.2  zinc finger and BTB domain-containing protein 38

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Conserved Domains (5) summary
      sd00017
      Location:1019 → 1039
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18223
      Location:15 → 128
      BTB_POZ_ZBTB38_CIBZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38)
      pfam00096
      Location:1045 → 1067
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1032 → 1055
      zf-H2C2_2; Zinc-finger double domain
      pfam15909
      Location:308 → 401
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      106124181..106231215 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265581.1 → XP_063121651.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000103824.1, ENSRNOT00000121360.1

    2. XM_063265579.1 → XP_063121649.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000095257.1, ENSRNOT00000102946.3

    3. XM_063265578.1 → XP_063121648.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000081285.1, ENSRNOT00000111528.2

    4. XM_063265582.1 → XP_063121652.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000067350.1, ENSRNOT00000016625.8

    5. XM_063265575.1 → XP_063121645.1  zinc finger and BTB domain-containing protein 38 isoform X1

      UniProtKB/TrEMBL
      A6I286

    6. XM_063265584.1 → XP_063121654.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000108939.1, ENSRNOT00000154527.1

    7. XM_063265583.1 → XP_063121653.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7

    8. XM_063265576.1 → XP_063121646.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7
      Related
      ENSRNOP00000098232.1, ENSRNOT00000120592.2

    9. XM_063265577.1 → XP_063121647.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7

    10. XM_063265580.1 → XP_063121650.1  zinc finger and BTB domain-containing protein 38 isoform X2

      UniProtKB/TrEMBL
      A6I286, M0RCM7

    RNA

    1. XR_010053975.1 RNA Sequence

    2. XR_010053976.1 RNA Sequence

    3. XR_010053974.1 RNA Sequence

    4. XR_010053973.1 RNA Sequence

    5. XR_010053978.1 RNA Sequence

    6. XR_010053977.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EXX3.1 GenPept UniProtKB/Swiss-Prot:Q5EXX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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