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    Pkia cAMP-dependent protein kinase inhibitor alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114906, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkiaprovided by RGD
    Official Full Name
    cAMP-dependent protein kinase inhibitor alphaprovided by RGD
    Primary source
    RGD:621021
    See related
    EnsemblRapid:ENSRNOG00000012095 AllianceGenome:RGD:621021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Predicted to be involved in negative regulation of cAMP/PKA signal transduction. Predicted to act upstream of or within negative regulation of macromolecule metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1107.0), Heart (RPKM 683.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkia in Genome Data Viewer
    Location:
    2q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (96306181..96380959, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (94398869..94473638, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (96593185..96668222, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene testis expressed 2, pseudogene 1 Neighboring gene RNA, U6 small nuclear 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The alpha- and beta-isoforms of the inhibitor protein of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase: characteristics and tissue- and developmental-specific expression. Van Patten SM, et al. Mol Endocrinol, 1992 Dec. PMID 1491692
    2. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. Wen W, et al. J Biol Chem, 1995 Feb 3. PMID 7836431
    3. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Knighton DR, et al. Science, 1991 Jul 26. PMID 1862342
    4. Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase. Collins SP, et al. J Biol Chem, 1997 Jul 18. PMID 9218452
    5. Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor. Baude EJ, et al. J Biol Chem, 1994 Jan 21. PMID 7905001

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase A catalytic subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cAMP/PKA signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase inhibitor alpha
    Names
    PKI-alpha
    protein kinase (cAMP-dependent, catalytic) inhibitor alpha
    protein kinase inhibitor, alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053772.2 → NP_446224.1  cAMP-dependent protein kinase inhibitor alpha

      See identical proteins and their annotated locations for NP_446224.1

      Status: VALIDATED

      Source sequence(s)
      FM055544, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P63249
      UniProtKB/TrEMBL
      A6IH81
      Related
      ENSRNOP00000103481.1, ENSRNOT00000160176.1
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      96306181..96380959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232155.5 → XP_006232217.1  cAMP-dependent protein kinase inhibitor alpha isoform X1

      See identical proteins and their annotated locations for XP_006232217.1

      UniProtKB/Swiss-Prot
      P63249
      UniProtKB/TrEMBL
      A6IH81
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor

    2. XM_006232153.4 → XP_006232215.1  cAMP-dependent protein kinase inhibitor alpha isoform X2

      UniProtKB/TrEMBL
      A0A8L2Q830
      Related
      ENSRNOP00000016567.2, ENSRNOT00000016567.5
      Conserved Domains (1) summary
      pfam02827
      Location:44 → 112
      PKI; cAMP-dependent protein kinase inhibitor

    3. XM_008760857.3 → XP_008759079.2  cAMP-dependent protein kinase inhibitor alpha isoform X1

      UniProtKB/Swiss-Prot
      P63249
      UniProtKB/TrEMBL
      A6IH81
      Conserved Domains (1) summary
      pfam02827
      Location:2 → 70
      PKI; cAMP-dependent protein kinase inhibitor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63249.2 GenPept UniProtKB/Swiss-Prot:P63249

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