U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hcrt hypocretin neuropeptide precursor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25723, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hcrtprovided by RGD
    Official Full Name
    hypocretin neuropeptide precursorprovided by RGD
    Primary source
    RGD:2786
    See related
    EnsemblRapid:ENSRNOG00000018892 AllianceGenome:RGD:2786
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    orexin-A
    Summary
    Enables neuropeptide hormone activity; type 1 orexin receptor binding activity; and type 2 orexin receptor binding activity. Involved in several processes, including excitatory postsynaptic potential; regulation of metal ion transport; and regulation of transmission of nerve impulse. Located in secretory granule. Is active in neuronal dense core vesicle lumen. Biomarker of hyperglycemia; obesity; and sleeping sickness. Human ortholog(s) of this gene implicated in heroin dependence and narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 9.9) and Testes (RPKM 2.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Hcrt in Genome Data Viewer
    Location:
    10q31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86190289..86191524, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85689979..85691214, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88669216..88670430, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAB5C, member RAS oncogene family Neighboring gene potassium voltage-gated channel subfamily H member 4 Neighboring gene uncharacterized LOC108352136 Neighboring gene GH3 domain containing Neighboring gene signal transducer and activator of transcription 5B

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables neuropeptide hormone activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide hormone activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neuropeptide hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables type 1 orexin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 1 orexin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables type 2 orexin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables type 2 orexin receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in behavioral fear response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in eating behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in eating behavior IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in feeding behavior NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transmission of nerve impulse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transmission of nerve impulse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transmission of nerve impulse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of neurotransmitter secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to alcohol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sleep IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in temperature homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in neuronal dense core vesicle lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hypocretin neuropeptide precursor
    Names
    Hypocretin (orexin) neuropeptide
    orexin
    prepro-orexin
    preprohypocretin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013179.3NP_037311.1  hypocretin neuropeptide precursor precursor

      See identical proteins and their annotated locations for NP_037311.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O55232
      UniProtKB/TrEMBL
      A6HJ60
      Related
      ENSRNOP00000025547.1, ENSRNOT00000025547.5
      Conserved Domains (1) summary
      pfam02072
      Location:1129
      Orexin; Prepro-orexin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86190289..86191524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)