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    Adora3 adenosine A3 receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911796, updated on 9-Dec-2024

    Summary

    Symbol
    Adora3provided by RGD
    Full Name
    adenosine A3 receptorprovided by RGD
    Primary source
    RGD:2051
    See related
    EnsemblRapid:ENSRNOG00000015788 AllianceGenome:RGD:2051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A3; TGPCR1
    Summary
    Enables G protein-coupled adenosine receptor activity. Involved in G protein-coupled receptor signaling pathway; presynaptic modulation of chemical synaptic transmission; and regulation of norepinephrine secretion. Located in presynaptic membrane. Is active in Schaffer collateral - CA1 synapse. Orthologous to human ADORA3 (adenosine A3 receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Adora3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196077042..196080686)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193352759..193392946)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208492231..208536910)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene uncharacterized LOC134485666 Neighboring gene SUB1 regulator of transcription, pseudogene 4 Neighboring gene similar to human chromosome 1 open reading frame 162 Neighboring gene ATP synthase peripheral stalk-membrane subunit b

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled adenosine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled adenosine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables G protein-coupled adenosine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled adenosine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within G protein-coupled adenosine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histamine secretion by mast cell ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of mucus secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of norepinephrine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in neuromuscular junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adenosine receptor A3
    Names
    adenosine receptor A3-like
    putative G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302750.1NP_001289679.1  adenosine receptor A3 isoform a

      See identical proteins and their annotated locations for NP_001289679.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A3i) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      Q4PKD9
      Related
      ENSRNOP00000021236.3, ENSRNOT00000021236.5
      Conserved Domains (2) summary
      pfam00001
      Location:31301
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:23126
      7tm_4; Olfactory receptor
    2. NM_001302751.1NP_001289680.1  adenosine receptor A3 isoform b

      See identical proteins and their annotated locations for NP_001289680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A3) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant A3i, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P28647, Q63792
      UniProtKB/TrEMBL
      A6HUN6, Q4PKD9
      Conserved Domains (2) summary
      pfam00001
      Location:31284
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:23176
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196077042..196080686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)