U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Grb2 growth factor receptor bound protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81504, updated on 27-Nov-2024

    Summary

    Symbol
    Grb2provided by RGD
    Full Name
    growth factor receptor bound protein 2provided by RGD
    Primary source
    RGD:619758
    See related
    EnsemblRapid:ENSRNOG00000003990 AllianceGenome:RGD:619758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ash-psi
    Summary
    Enables several functions, including epidermal growth factor receptor binding activity; insulin receptor substrate binding activity; and phosphotyrosine residue binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; natural killer cell mediated cytotoxicity; and nervous system development. Predicted to act upstream of or within several processes, including embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; and positive regulation of actin filament polymerization. Part of protein-containing complex. Is active in presynapse. Human ortholog(s) of this gene implicated in breast cancer; prostate adenocarcinoma; and prostate cancer. Orthologous to human GRB2 (growth factor receptor bound protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 244.2), Brain (RPKM 239.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Grb2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101380354..101448138, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (100881404..100949193, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104193953..104263071, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene high mobility group protein B1-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC108668

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables SH3 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ephrin receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables epidermal growth factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables epidermal growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables epidermal growth factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin receptor substrate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables insulin receptor substrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotrophin TRKA receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotrophin TRKA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane receptor protein tyrosine kinase adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane receptor protein tyrosine kinase adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Ras protein signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Schwann cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Schwann cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within anatomical structure formation involved in morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in branching involved in labyrinthine layer morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to ionizing radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within endodermal cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction in response to DNA damage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
     
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of COP9 signalosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Grb2-EGFR complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Grb2-EGFR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    growth factor receptor-bound protein 2
    Names
    SH2/SH3 adapter GRB2
    adapter protein GRB2
    growth factor receptor-bound protein 2-like
    protein Ash

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030846.2NP_110473.2  growth factor receptor-bound protein 2

      See identical proteins and their annotated locations for NP_110473.2

      Status: VALIDATED

      Source sequence(s)
      AA926364, BC091144
      UniProtKB/Swiss-Prot
      P62994, Q5BKA7
      UniProtKB/TrEMBL
      A0A8L2Q1H5, A6HKQ4
      Related
      ENSRNOP00000005347.6, ENSRNOT00000005347.7
      Conserved Domains (3) summary
      cd09941
      Location:56150
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11946
      Location:156
      SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
      cd11949
      Location:160212
      SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101380354..101448138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)