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    Serpina3j serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J [ Mus musculus (house mouse) ]

    Gene ID: 238395, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpina3jprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3Jprovided by MGI
    Primary source
    MGI:MGI:2182843
    See related
    Ensembl:ENSMUSG00000079013 AllianceGenome:MGI:2182843
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4931; EG238395
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Serpina3j in Genome Data Viewer
    Location:
    12 E; 12 53.92 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104266981..104286845)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104300722..104320586)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3H Neighboring gene STARR-seq mESC enhancer starr_33134 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3I Neighboring gene microRNA 12183 Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3K Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3L, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817
    2. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    3. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J
    Names
    alpha-1 antiproteinase
    serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101472.2 → NP_001094942.1  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J precursor

      See identical proteins and their annotated locations for NP_001094942.1

      Status: VALIDATED

      Source sequence(s)
      AC117194
      Consensus CDS
      CCDS49158.1
      UniProtKB/TrEMBL
      D3Z451
      Related
      ENSMUSP00000105583.3, ENSMUST00000109957.3
      Conserved Domains (1) summary
      cd19551
      Location:37 → 417
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104266981..104286845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515858.1 → XP_006515921.1  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J isoform X1

      See identical proteins and their annotated locations for XP_006515921.1

      UniProtKB/TrEMBL
      D3Z451
      Conserved Domains (1) summary
      cd19551
      Location:37 → 417
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    2. XM_006515859.1 → XP_006515922.1  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J isoform X2

      Conserved Domains (1) summary
      cd19551
      Location:37 → 353
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    3. XM_006515857.1 → XP_006515920.1  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J isoform X1

      See identical proteins and their annotated locations for XP_006515920.1

      UniProtKB/TrEMBL
      D3Z451
      Conserved Domains (1) summary
      cd19551
      Location:37 → 417
      serpinA3_A1AC; serpin family A member 3, alpha 1-antichymotrypsin

    4. XM_017315065.1 → XP_017170554.1  serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J isoform X3

      Conserved Domains (1) summary
      cl38926
      Location:37 → 304
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version

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