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    Zfp60 zinc finger protein 60 [ Mus musculus (house mouse) ]

    Gene ID: 22718, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp60provided by MGI
    Official Full Name
    zinc finger protein 60provided by MGI
    Primary source
    MGI:MGI:99207
    See related
    Ensembl:ENSMUSG00000037640 AllianceGenome:MGI:99207
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mfg3; Mfg-3; 6330516O17Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; immune system; and nervous system. Orthologous to human ZNF780A (zinc finger protein 780A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 13.6), CNS E14 (RPKM 12.9) and 19 other tissues See more
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    Genomic context

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    See Zfp60 in Genome Data Viewer
    Location:
    7 A3; 7 15.97 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (27430834..27451114)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27731409..27751689)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18383 Neighboring gene zinc finger protein 607B Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28474189-28474376 Neighboring gene STARR-seq mESC enhancer starr_18384 Neighboring gene PHD finger protein 5B, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28516760-28516943 Neighboring gene STARR-seq mESC enhancer starr_18388 Neighboring gene STARR-seq mESC enhancer starr_18389 Neighboring gene predicted gene 10046 Neighboring gene predicted gene, 29810

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Zfp60, a mouse zinc finger gene expressed transiently during in vitro muscle differentiation. Perez M, et al. FEBS Lett, 1996 Jun 3. PMID 8674531
    2. Mouse genes coding for "zinc-finger"-containing proteins: characterization and expression in differentiated cells. Passananti C, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2512579, Free PMC Article
    3. The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation. Ganss B, et al. J Bone Miner Res, 2002 Dec. PMID 12469909
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. role as negative regulator of cartilage differentiation
      Title: The zinc finger transcription factor Zfp60 is a negative regulator of cartilage differentiation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 60
    Names
    zfp-60
    zinc finger protein Mfg-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009560.2 → NP_033586.2  zinc finger protein 60

      See identical proteins and their annotated locations for NP_033586.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA718695, AC074312, CAAA01066021, CB526626
      Consensus CDS
      CCDS21030.1
      UniProtKB/TrEMBL
      Q8K0D9
      Related
      ENSMUSP00000036627.8, ENSMUST00000042641.14
      Conserved Domains (5) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:212 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:636 → 658
      zf-H2C2_2; Zinc-finger double domain

    2. NM_029531.2 → NP_083807.2  zinc finger protein 60

      See identical proteins and their annotated locations for NP_083807.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK149305, CAAA01066021
      Consensus CDS
      CCDS21030.1
      UniProtKB/TrEMBL
      Q8K0D9
      Related
      ENSMUSP00000103973.2, ENSMUST00000108336.8
      Conserved Domains (5) summary
      smart00349
      Location:14 → 75
      KRAB; krueppel associated box
      COG5048
      Location:212 → 640
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:511 → 531
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:636 → 658
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      27430834..27451114
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P16374.2 GenPept UniProtKB/Swiss-Prot:P16374

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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