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    Myrf myelin regulatory factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293736, updated on 3-Dec-2024

    Summary

    Official Symbol
    Myrfprovided by RGD
    Official Full Name
    myelin regulatory factorprovided by RGD
    Primary source
    RGD:1306622
    See related
    EnsemblRapid:ENSRNOG00000028274 AllianceGenome:RGD:1306622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrf; RGD1306622
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in positive regulation of oligodendrocyte differentiation; response to cocaine; and response to immobilization stress. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in endoplasmic reticulum membrane and nucleus. Human ortholog(s) of this gene implicated in cerebral infarction; congenital diaphragmatic hernia; hyperopia; nanophthalmos; and primary angle-closure glaucoma. Orthologous to human MYRF (myelin regulatory factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 49.8), Lung (RPKM 39.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Myrf in Genome Data Viewer
    Location:
    1q43
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216279057..216311155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (206854175..206886276, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226260558..226292650, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 1 Neighboring gene transmembrane protein 258 Neighboring gene flap structure-specific endonuclease 1 Neighboring gene diacylglycerol lipase, alpha Neighboring gene ribosomal protein L10, pseudogene 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    myelin regulatory factor
    Names
    myelin gene regulatory factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170487.1NP_001163958.1  myelin regulatory factor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ACZ2, D4A352
      Conserved Domains (5) summary
      pfam05224
      Location:392539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:10071138
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216279057..216311155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231030.5XP_006231092.1  myelin regulatory factor isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACZ2
      Related
      ENSRNOP00000035676.6, ENSRNOT00000039133.7
      Conserved Domains (5) summary
      pfam05224
      Location:392539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:10061137
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)
    2. XM_063286961.1XP_063143031.1  myelin regulatory factor isoform X5

      UniProtKB/TrEMBL
      A0A8I6ACZ2
    3. XM_008760221.3XP_008758443.1  myelin regulatory factor isoform X4

      UniProtKB/TrEMBL
      A0A8I6ARG5
      Related
      ENSRNOP00000092057.2, ENSRNOT00000114113.2
      Conserved Domains (5) summary
      pfam05224
      Location:304451
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:498558
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:578613
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:9191050
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:190243
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)
    4. XM_008760220.3XP_008758442.1  myelin regulatory factor isoform X3

      UniProtKB/TrEMBL
      A0A8I6ACZ2
      Conserved Domains (6) summary
      TIGR02600
      Location:768866
      Verru_Chthon_A; Verru_Chthon cassette protein A
      pfam05224
      Location:392539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:9791110
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)
    5. XM_006231031.4XP_006231093.1  myelin regulatory factor isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACZ2, A0A8I6AIU7
      Related
      ENSRNOP00000095013.1, ENSRNOT00000094966.2
      Conserved Domains (6) summary
      TIGR02600
      Location:768867
      Verru_Chthon_A; Verru_Chthon cassette protein A
      pfam05224
      Location:392539
      NDT80_PhoG; NDT80 / PhoG like DNA-binding family
      pfam13884
      Location:586646
      Peptidase_S74; Chaperone of endosialidase
      pfam13887
      Location:666701
      MRF_C1; Myelin gene regulatory factor -C-terminal domain 1
      pfam13888
      Location:9801111
      MRF_C2; Myelin gene regulatory factor C-terminal domain 2
      cl01455
      Location:278331
      PhnH; Bacterial phosphonate metabolizm protein (PhnH)