Tmprss11g transmembrane protease, serine 11g [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmprss11gprovided by MGI
Official Full Name: transmembrane protease, serine 11gprovided by MGI
Primary source: MGI:MGI:2444058
See related: Ensembl:ENSMUSG00000079451 AllianceGenome:MGI:2444058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Desc4; 9930032O22Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in plasma membrane. Orthologous to human TMPRSS11GP (transmembrane serine protease 11G, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 5 E1; 5 43.56 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (86633736..86666459, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (86485877..86518600, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protease serine 11G

Names: serine protease Desc4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177162.4 → NP_796136.2 transmembrane protease serine 11G

See identical proteins and their annotated locations for NP_796136.2

Status: VALIDATED

Source sequence(s)

AK036981, AK037029, CK627573

Consensus CDS

CCDS51532.1

UniProtKB/Swiss-Prot

Q8BZ04, Q8BZ10

UniProtKB/TrEMBL

Q147T9

Related

ENSMUSP00000122709.2, ENSMUST00000134179.8

Conserved Domains (3) summary

smart00020
Location:185 → 411

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:186 → 414

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

pfam01390
Location:48 → 142

SEA; SEA domain