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    Tcof1 treacle ribosome biogenesis factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291571, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tcof1provided by RGD
    Official Full Name
    treacle ribosome biogenesis factor 1provided by RGD
    Primary source
    RGD:1309850
    See related
    EnsemblRapid:ENSRNOG00000026108 AllianceGenome:RGD:1309850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein heterodimerization activity; protein-macromolecule adaptor activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 87.7), Thymus (RPKM 81.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tcof1 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (56537437..56570727, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (54267015..54300324, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (56081863..56115719, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14 Neighboring gene CD74 molecule Neighboring gene uncharacterized LOC102550733 Neighboring gene arylsulfatase family, member I

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural crest formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nucleolar large rRNA transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within nucleolar large rRNA transcription by RNA polymerase I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    treacle protein
    Names
    Treacher Collins-Franceschetti syndrome 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395127.1NP_001382056.1  treacle protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6AJL5
      Related
      ENSRNOP00000045755.6, ENSRNOT00000045041.7
      Conserved Domains (3) summary
      smart00667
      Location:638
      LisH; Lissencephaly type-1-like homology motif
      PHA03247
      Location:6341071
      PHA03247; large tegument protein UL36; Provisional
      pfam03546
      Location:306790
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      56537437..56570727 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106143.1: Suppressed sequence

      Description
      NM_001106143.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.