Srp14 signal recognition particle 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srp14provided by MGI
Official Full Name: signal recognition particle 14provided by MGI
Primary source: MGI:MGI:107169
See related: Ensembl:ENSMUSG00000009549 AllianceGenome:MGI:107169
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 14kDa
Summary: Predicted to enable 7S RNA binding activity and endoplasmic reticulum signal peptide binding activity. Predicted to be involved in protein targeting to ER. Predicted to be located in nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Is expressed in 4-cell stage embryo; cerebral cortex; ganglia; and thymus primordium. Orthologous to human SRP14 (signal recognition particle 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 71.5), CNS E14 (RPKM 67.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.4 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (118306324..118310177, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (118475843..118479696, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Srp14 (e-PCR), detects polymorphism
- UniSTS:536606

Srp14 (e-PCR), detects polymorphism
- UniSTS:536607

AW536328 (e-PCR)
- UniSTS:178678

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 7S RNA binding	IEA Inferred from Electronic Annotation more info
enables endoplasmic reticulum signal peptide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to ER	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of signal recognition particle, endoplasmic reticulum targeting	IBA Inferred from Biological aspect of Ancestor more info
part_of signal recognition particle, endoplasmic reticulum targeting	IEA Inferred from Electronic Annotation more info
part_of signal recognition particle, endoplasmic reticulum targeting	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal recognition particle 14 kDa protein

Names: (homologous Alu RNA binding protein); homologous Alu RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.