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    Gata4 GATA binding protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54254, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gata4provided by RGD
    Official Full Name
    GATA binding protein 4provided by RGD
    Primary source
    RGD:2665
    See related
    EnsemblRapid:ENSRNOG00000010708 AllianceGenome:RGD:2665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; positive regulation of BMP signaling pathway; and transdifferentiation. Predicted to be located in chromatin and nuclear body. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Used to study myocardial infarction. Biomarker of congenital heart disease and pulmonary hypertension. Human ortholog(s) of this gene implicated in congenital heart disease (multiple). Orthologous to human GATA4 (GATA binding protein 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 136.0), Testes (RPKM 66.9) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Gata4 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41635572..41707252, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (37459601..37531291, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (46386703..46458679, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482130 Neighboring gene farnesyl diphosphate farnesyl transferase 1 Neighboring gene nei-like DNA glycosylase 2 Neighboring gene uncharacterized LOC102548615 Neighboring gene uncharacterized LOC120097012 Neighboring gene BLK proto-oncogene, Src family tyrosine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables NFAT protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables co-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial septum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial septum primum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrial septum secundum morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrioventricular canal development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in atrioventricular valve formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within atrioventricular valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac muscle tissue regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac right ventricle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cardiac septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell growth involved in cardiac muscle cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucose stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to gonadotropin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic foregut morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endocardial cushion development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoderm formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within gastrulation with mouth forming second ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in heart looping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intestinal epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung lobe formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of connective tissue replacement ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of miRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cardiac muscle cell contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to estrogen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to mechanical stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within seminiferous tubule development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in transdifferentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ventricular cardiac muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription factor GATA-4
    Names
    DNA-binding protein GATA-GT2
    GATA-binding factor 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144730.1NP_653331.1  transcription factor GATA-4

      See identical proteins and their annotated locations for NP_653331.1

      Status: PROVISIONAL

      Source sequence(s)
      L22761
      UniProtKB/Swiss-Prot
      P46152
      UniProtKB/TrEMBL
      A6K6F9
      Related
      ENSRNOP00000014320.3, ENSRNOT00000014320.7
      Conserved Domains (2) summary
      cd00202
      Location:269320
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41635572..41707252 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274589.1XP_063130659.1  transcription factor GATA-4 isoform X2

      UniProtKB/Swiss-Prot
      P46152
      UniProtKB/TrEMBL
      A6K6F9
    2. XM_017599788.3XP_017455277.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal
    3. XM_006252189.5XP_006252251.1  transcription factor GATA-4 isoform X1

      Conserved Domains (3) summary
      smart00401
      Location:268315
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:270321
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
      pfam05349
      Location:1204
      GATA-N; GATA-type transcription activator, N-terminal