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    Zp3 zona pellucida glycoprotein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114639, updated on 27-Nov-2024

    Summary

    Official Symbol
    Zp3provided by RGD
    Official Full Name
    zona pellucida glycoprotein 3provided by RGD
    Primary source
    RGD:620606
    See related
    EnsemblRapid:ENSRNOG00000001434 AllianceGenome:RGD:620606
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zp-3
    Summary
    Predicted to enable several functions, including acrosin binding activity; identical protein binding activity; and receptor ligand activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in several processes, including oogenesis; positive regulation of immune response; and regulation of gene expression. Predicted to be located in several cellular components, including collagen-containing extracellular matrix; egg coat; and extracellular space. Predicted to be active in extracellular matrix. Orthologous to human ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 3.6), Thymus (RPKM 1.5) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zp3 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26327161..26334126, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20690547..20697513, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23735225..23752734, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095913 Neighboring gene U6 spliceosomal RNA Neighboring gene uroplakin 3B Neighboring gene deltex E3 ubiquitin ligase 2 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene U6 spliceosomal RNA Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acrosin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acrosin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor ligand activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables structural constituent of egg coat IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of egg coat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in binding of sperm to zona pellucida IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in blastocyst formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blastocyst formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blastocyst formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in egg coat formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in egg coat formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in egg coat formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in egg coat formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in humoral immune response mediated by circulating immunoglobulin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in humoral immune response mediated by circulating immunoglobulin ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of binding of sperm to zona pellucida ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of acrosomal vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acrosomal vesicle exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of acrosome reaction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of acrosome reaction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of acrosome reaction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of antral ovarian follicle growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of antral ovarian follicle growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of antral ovarian follicle growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of humoral immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of humoral immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-4 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-4 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-4 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of type IV hypersensitivity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type IV hypersensitivity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type IV hypersensitivity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in collagen-containing extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in egg coat IEA
    Inferred from Electronic Annotation
    more info
     
    located_in egg coat ISO
    Inferred from Sequence Orthology
    more info
     
    located_in egg coat ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zona pellucida sperm-binding protein 3
    Names
    zona pellucida glycoprotein 3 (sperm receptor)
    zona pellucida glycoprotein ZP3
    zona pellucida protein C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053762.1NP_446214.1  zona pellucida sperm-binding protein 3 precursor

      See identical proteins and their annotated locations for NP_446214.1

      Status: PROVISIONAL

      Source sequence(s)
      D78482
      UniProtKB/TrEMBL
      A1L124, F7EZ23
      Related
      ENSRNOP00000001952.3, ENSRNOT00000001952.6
      Conserved Domains (2) summary
      smart00241
      Location:45304
      ZP; Zona pellucida (ZP) domain
      pfam00100
      Location:183302
      Zona_pellucida; Zona pellucida-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26327161..26334126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)