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    ZNF644 zinc finger protein 644 [ Homo sapiens (human) ]

    Gene ID: 84146, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZNF644provided by HGNC
    Official Full Name
    zinc finger protein 644provided by HGNC
    Primary source
    HGNC:HGNC:29222
    See related
    Ensembl:ENSG00000122482 MIM:614159; AllianceGenome:HGNC:29222
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NatF; MYP21; ZEP-2; BM-005
    Summary
    The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 9.2), endometrium (RPKM 7.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF644 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (90915304..91022035, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (90759864..90867341, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91380861..91487592, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1063 Neighboring gene long intergenic non-protein coding RNA 1763 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:91356676-91357355 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:91390503-91391117 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:91392347-91392959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:91393061-91393667 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:91393668-91394273 Neighboring gene phosphorylase kinase regulatory subunit alpha 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:91439231-91440124 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:91487399-91487948 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:91487949-91488498 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:91486849-91487398 Neighboring gene ribosomal protein L5 pseudogene 6 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:91589111-91589852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:91654217-91654717 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:91717359-91717859 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:91718677-91718849 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:91755191-91755405 Neighboring gene helicase for meiosis 1 Neighboring gene flap structure-specific endonuclease 1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Myopia 21, autosomal dominant
    MedGen: C3279997 OMIM: 614167 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide association study of the metabolic syndrome in Indian Asian men.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1221, MGC60165, MGC70410

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 644
    Names
    zinc finger motif enhancer binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029760.1 RefSeqGene

      Range
      5221..111952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_016620.4NP_057704.2  zinc finger protein 644 isoform 2

      See identical proteins and their annotated locations for NP_057704.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
      Source sequence(s)
      AB033047, DA147194
      Consensus CDS
      CCDS732.1
      UniProtKB/Swiss-Prot
      Q9H582
      Related
      ENSP00000340828.5, ENST00000347275.9
    2. NM_032186.5NP_115562.3  zinc finger protein 644 isoform 2

      See identical proteins and their annotated locations for NP_115562.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 3 both encode isoform 2.
      Source sequence(s)
      AB033047, BI760689
      Consensus CDS
      CCDS732.1
      UniProtKB/Swiss-Prot
      Q9H582
      Related
      ENSP00000354659.5, ENST00000361321.5
    3. NM_201269.3NP_958357.1  zinc finger protein 644 isoform 1

      See identical proteins and their annotated locations for NP_958357.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC132776, BC150177, BX477299
      Consensus CDS
      CCDS731.1
      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
      Related
      ENSP00000337008.5, ENST00000337393.10
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      90915304..91022035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542258.4XP_011540560.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540560.1

      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    2. XM_017002493.3XP_016857982.1  zinc finger protein 644 isoform X3

      UniProtKB/Swiss-Prot
      Q9H582
    3. XM_017002488.3XP_016857977.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    4. XM_005271257.6XP_005271314.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_005271314.1

      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    5. XM_047431972.1XP_047287928.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    6. XM_011542260.4XP_011540562.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540562.1

      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    7. XM_017002492.3XP_016857981.1  zinc finger protein 644 isoform X3

      UniProtKB/Swiss-Prot
      Q9H582
    8. XM_047431980.1XP_047287936.1  zinc finger protein 644 isoform X3

    9. XM_017002489.3XP_016857978.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    10. XM_005271260.6XP_005271317.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_005271317.1

      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    11. XM_047431965.1XP_047287921.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    12. XM_047431936.1XP_047287892.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    13. XM_047431973.1XP_047287929.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    14. XM_047431938.1XP_047287894.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    15. XM_017002491.3XP_016857980.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
      Related
      ENSP00000359469.1, ENST00000370440.5
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    16. XM_011542261.4XP_011540563.1  zinc finger protein 644 isoform X1

      See identical proteins and their annotated locations for XP_011540563.1

      UniProtKB/TrEMBL
      A7E234
      Conserved Domains (3) summary
      sd00017
      Location:498518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:412432
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl19114
      Location:438501
      RNAP_largest_subunit_N; Largest subunit of RNA polymerase (RNAP), N-terminal domain
    17. XM_047431962.1XP_047287918.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    18. XM_047431934.1XP_047287890.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      90759864..90867341 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339106.1XP_054195081.1  zinc finger protein 644 isoform X3

    2. XM_054339097.1XP_054195072.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    3. XM_054339091.1XP_054195066.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    4. XM_054339100.1XP_054195075.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    5. XM_054339102.1XP_054195077.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    6. XM_054339095.1XP_054195070.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    7. XM_054339089.1XP_054195064.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    8. XM_054339104.1XP_054195079.1  zinc finger protein 644 isoform X3

    9. XM_054339099.1XP_054195074.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    10. XM_054339090.1XP_054195065.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    11. XM_054339101.1XP_054195076.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    12. XM_054339093.1XP_054195068.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    13. XM_054339105.1XP_054195080.1  zinc finger protein 644 isoform X3

    14. XM_054339094.1XP_054195069.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    15. XM_054339098.1XP_054195073.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    16. XM_054339092.1XP_054195067.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234
    17. XM_054339103.1XP_054195078.1  zinc finger protein 644 isoform X2

      UniProtKB/Swiss-Prot
      A2RU71, Q2TAM0, Q5TCC0, Q6BEP7, Q6P446, Q6PI06, Q7LG67, Q9H582, Q9ULJ9
      UniProtKB/TrEMBL
      A7E234
    18. XM_054339096.1XP_054195071.1  zinc finger protein 644 isoform X1

      UniProtKB/TrEMBL
      A7E234