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    ZBED3-AS1 ZBED3 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 728723, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZBED3-AS1provided by HGNC
    Official Full Name
    ZBED3 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:44188
    See related
    Ensembl:ENSG00000250802 AllianceGenome:HGNC:44188
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    lnc13728
    Expression
    Broad expression in thyroid (RPKM 2.3), fat (RPKM 2.0) and 17 other tissues See more
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    Genomic context

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    See ZBED3-AS1 in Genome Data Viewer
    Location:
    5q13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (77086715..77149301)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (77568346..77631222)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76382540..76445126)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76325887-76326466 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76326467-76327046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16108 Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76383973-76384573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76383370-76383972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:76382768-76383369 Neighboring gene small nucleolar RNA, H/ACA box 47 Neighboring gene uncharacterized LOC124901008 Neighboring gene zinc finger BED-type containing 3 Neighboring gene phosphodiesterase 8B Neighboring gene Sharpr-MPRA regulatory region 15273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:76468397-76468898 Neighboring gene high mobility group box 1 pseudogene 35 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:76618089-76618784 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:76672412-76673040 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:76752518-76752693 Neighboring gene uncharacterized LOC124901009 Neighboring gene WD repeat domain 41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma. Dong J, et al. Eur J Pharmacol, 2023 Jan 5. PMID 36462734
    2. Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/β-catenin pathway. Xu H, et al. Stem Cell Res Ther, 2021 Mar 12. PMID 33712067, Free PMC Article
    3. Long noncoding RNAs expression signatures in chondrogenic differentiation of human bone marrow mesenchymal stem cells. Wang L, et al. Biochem Biophys Res Commun, 2015 Jan 2. PMID 25482444
    4. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Voight BF, et al. Nat Genet, 2010 Jul. PMID 20581827, Free PMC Article
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma.
      Title: Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma.
    2. Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/beta-catenin pathway.
      Title: Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/β-catenin pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Readthrough PDE8B

    Readthrough gene: PDE8B

    Other Names

    • CTC-564N23.3
    • ZBED3 antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024398.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    2. NR_182763.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    3. NR_182764.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    4. NR_182765.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    5. NR_182766.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581
      Related
      ENST00000643269.1

    6. NR_182767.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    7. NR_182768.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    8. NR_182769.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    9. NR_182770.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    10. NR_182771.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008581

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      77086715..77149301
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      77568346..77631222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials