Tpm3 tropomyosin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpm3provided by RGD
Official Full Name: tropomyosin 3provided by RGD
Primary source: RGD:621546
See related: EnsemblRapid:ENSRNOG00000017441 AllianceGenome:RGD:621546
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tpm5; TM30nm
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in brush border. Human ortholog(s) of this gene implicated in congenital myopathy 4A and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 928.6), Spleen (RPKM 397.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (177812534..177842661)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (175517198..175545014)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (189423534..189451340)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
Title: [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].
Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Title: Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
All studied gamma-tropomyosin mutants reduced Ca-induced activation but had no effect on the inhibition of actomyosin cross-bridges.
Title: Functional effects of congenital myopathy-related mutations in gamma-tropomyosin gene.
variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations
Title: Tropomyosin isoform 3 promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments.
the main expression of Tpm3(3) takes place in the renal medulla, and its intensity differs in normal and Brattleboro diabetes insipidus mutant rats
Title: Expression of tropomyosin-encoding gene in the kidney depends on functioning of vasopressin gene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141892 (e-PCR)
- UniSTS:223884

RH133983 (e-PCR)
- UniSTS:217265

AW529957 (e-PCR)
- UniSTS:247499

U04541 (e-PCR)
- UniSTS:125645

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tropomyosin alpha-3 chain

Names: gamma-tropomyosin; nonmuscle tropomyosin 5; tropomyosin 3, gamma; tropomyosin non-muscle; tropomyosin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301285.1 → NP_001288214.1 tropomyosin alpha-3 chain isoform Tpm3.12st

Status: PROVISIONAL

Description

Transcript Variant: This variant (Tpm3.12, also known as variant 3) encodes the longest isoform (Tpm3.12st, also known as isoform 3). The encoded protein is a fast skeletal muscle isoform.

Source sequence(s)

FQ215580

Related

ENSRNOP00000035561.5, ENSRNOT00000029076.7

Conserved Domains (3) summary

pfam00261
Location:49 → 283

Tropomyosin; Tropomyosin

pfam07851
Location:181 → 275

TMPIT; TMPIT-like protein

pfam16526
Location:14 → 73

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
NM_001301286.1 → NP_001288215.1 tropomyosin alpha-3 chain isoform Tpm3.3cy

See identical proteins and their annotated locations for NP_001288215.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (Tpm3.3, also known as variant 4) differs in the 5' UTR and coding sequence compared to variant Tpm3.12. The resulting isoform (Tpm3.3cy, also known as isoform 4) has a shorter and distinct N-terminus compared to isoform Tpm3.12st.

Source sequence(s)

FQ215580, L24776

UniProtKB/TrEMBL

A6J6K0

Conserved Domains (1) summary

pfam00261
Location:12 → 246

Tropomyosin
NM_057208.2 → NP_476556.2 tropomyosin alpha-3 chain isoform Tpm3.4cy

See identical proteins and their annotated locations for NP_476556.2

Status: PROVISIONAL

Description

Transcript Variant: This variant (Tpm3.4, also known as variant 1) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.4cy, also known as isoform 1) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.

Source sequence(s)

L24777

UniProtKB/TrEMBL

A6J6J8

Related

ENSRNOP00000109938.1, ENSRNOT00000166501.1

Conserved Domains (1) summary

pfam00261
Location:12 → 245

Tropomyosin
NM_173111.2 → NP_775134.2 tropomyosin alpha-3 chain isoform Tpm3.1cy

Status: PROVISIONAL

Description

Transcript Variant: This variant (Tpm3.1, also known as variant 2) differs in both UTR's and the coding region but maintains the reading frame, compared to variant Tpm3.12. This results in an isoform (Tpm3.1cy, also known as isoform 2) that is shorter at both the N- and C-termini, compared to isoform Tpm3.12st.

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q63599, Q63600, Q63601, Q63610

UniProtKB/TrEMBL

A6J6J6

Conserved Domains (1) summary

pfam00261
Location:12 → 246

Tropomyosin