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    EXOC5 exocyst complex component 5 [ Homo sapiens (human) ]

    Gene ID: 10640, updated on 3-Dec-2024

    Summary

    Official Symbol
    EXOC5provided by HGNC
    Official Full Name
    exocyst complex component 5provided by HGNC
    Primary source
    HGNC:HGNC:10696
    See related
    Ensembl:ENSG00000070367 MIM:604469; AllianceGenome:HGNC:10696
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC10; HSEC10; SEC10P; PRO1912; SEC10L1
    Summary
    The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 9.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See EXOC5 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (57200507..57268905, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (51406949..51475352, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (57667225..57735623, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903323 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:57457567-57457754 Neighboring gene VISTA enhancer hs1791 Neighboring gene ribosomal protein L3 pseudogene 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:57496239-57496890 Neighboring gene uncharacterized LOC124903324 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:57526716-57527915 Neighboring gene zinc finger CCHC-type containing 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5791 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57735423-57736006 Neighboring gene adaptor related protein complex 5 subunit mu 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57810066-57810610 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57831098-57831989 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:57849692-57850526 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:57857288-57858283 Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp666H126

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in epithelial cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of planar polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in non-motile cilium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in post-Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    exocyst complex component 5
    Names
    SEC10-like 1
    exocyst complex component Sec10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006544.4NP_006535.1  exocyst complex component 5

      See identical proteins and their annotated locations for NP_006535.1

      Status: REVIEWED

      Source sequence(s)
      AA837306, AK025802, AL118623, AL139195, AL391152, BC041126, BI460915, BM723045, CB145811, CN268669, U85946
      Consensus CDS
      CCDS45111.1
      UniProtKB/Swiss-Prot
      B2R6C5, O00471, Q8IW24
      UniProtKB/TrEMBL
      B4DHG4
      Related
      ENSP00000484855.1, ENST00000621441.5
      Conserved Domains (2) summary
      pfam07393
      Location:89707
      Sec10; Exocyst complex component Sec10
      pfam10267
      Location:2584
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      57200507..57268905 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267272.4XP_005267329.1  exocyst complex component 5 isoform X1

      See identical proteins and their annotated locations for XP_005267329.1

      UniProtKB/TrEMBL
      B4DHG4
      Conserved Domains (1) summary
      pfam07393
      Location:127745
      Sec10; Exocyst complex component Sec10
    2. XM_047430882.1XP_047286838.1  exocyst complex component 5 isoform X2

      UniProtKB/TrEMBL
      B4DHG4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      51406949..51475352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375276.1XP_054231251.1  exocyst complex component 5 isoform X1

      UniProtKB/TrEMBL
      B4DHG4