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    KIF5B kinesin family member 5B [ Homo sapiens (human) ]

    Gene ID: 3799, updated on 27-Nov-2024

    Summary

    Official Symbol
    KIF5Bprovided by HGNC
    Official Full Name
    kinesin family member 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:6324
    See related
    Ensembl:ENSG00000170759 MIM:602809; AllianceGenome:HGNC:6324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KNS; KINH; KNS1; UKHC; HEL-S-61
    Summary
    Enables identical protein binding activity; microtubule binding activity; and microtubule motor activity. Involved in several processes, including natural killer cell mediated cytotoxicity; positive regulation of protein localization to plasma membrane; and vesicle transport along microtubule. Located in centriolar satellite; cytosol; and vesicle. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis (RPKM 44.1), gall bladder (RPKM 42.8) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF5B in Genome Data Viewer
    Location:
    10p11.22
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (32009015..32056425, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (32037647..32085426, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (32297943..32345353, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984219 Neighboring gene uncharacterized LOC105376485 Neighboring gene ribosomal protein L34 pseudogene 19 Neighboring gene RNA, 7SL, cytoplasmic 825, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:32291606-32292421 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:32306942-32308141 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:32337050-32338249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2281 Neighboring gene ribosomal protein S4X pseudogene 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:32411889-32412388 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:32428165-32428894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2282 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2283 Neighboring gene Sharpr-MPRA regulatory region 14665 Neighboring gene RNA, U7 small nuclear 22 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-1 CA relocalizes RANBP2 (NUP358) into the cytoplasm of infected cells, which requires CPSF6 and KIF5B PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag HIV-1 CA requires CPSF6 and KIF5B to relocalize RANBP2 (NUP358) into the cytoplasm of infected cells PubMed
    gag HIV-1 uncoating is facilitated by dynein motor function since siRNA knockdown of KIF5B increases the amount of HIV-1 p24 associated with cytoplasmic virions PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding HDA PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in anterograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytoplasm organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lysosome localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in microtubule-based movement TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitochondrion transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell mediated cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in plus-end-directed vesicle transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of modification of synapse structure, modulating synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retrograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in stress granule disassembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vesicle transport along microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vesicle transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    located_in ciliary rootlet IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytolytic granule membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-1 heavy chain
    Names
    conventional kinesin heavy chain
    epididymis secretory protein Li 61
    kinesin 1 (110-120kD)
    kinesin heavy chain
    ubiquitous kinesin heavy chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004521.3NP_004512.1  kinesin-1 heavy chain

      See identical proteins and their annotated locations for NP_004512.1

      Status: VALIDATED

      Source sequence(s)
      AL161932, BC065267, BP361225, BU633712, DC399931, X65873
      Consensus CDS
      CCDS7171.1
      UniProtKB/Swiss-Prot
      A0AVB2, P33176, Q5VZ85
      UniProtKB/TrEMBL
      A8K048, V9HW29
      Related
      ENSP00000307078.4, ENST00000302418.5
      Conserved Domains (3) summary
      COG4372
      Location:730922
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02168
      Location:414803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd01369
      Location:6325
      KISc_KHC_KIF5; Kinesin motor domain, kinesin heavy chain (KHC) or KIF5-like subgroup

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      32009015..32056425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425203.1XP_047281159.1  kinesin-1 heavy chain isoform X2

    2. XM_047425202.1XP_047281158.1  kinesin-1 heavy chain isoform X1

      UniProtKB/Swiss-Prot
      A0AVB2, P33176, Q5VZ85
      UniProtKB/TrEMBL
      V9HW29

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      32037647..32085426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365846.1XP_054221821.1  kinesin-1 heavy chain isoform X2

    2. XM_054365845.1XP_054221820.1  kinesin-1 heavy chain isoform X1

      UniProtKB/Swiss-Prot
      A0AVB2, P33176, Q5VZ85
      UniProtKB/TrEMBL
      V9HW29