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    ZYG11B zyg-11 family member B, cell cycle regulator [ Homo sapiens (human) ]

    Gene ID: 79699, updated on 3-Dec-2024

    Summary

    Official Symbol
    ZYG11Bprovided by HGNC
    Official Full Name
    zyg-11 family member B, cell cycle regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:25820
    See related
    Ensembl:ENSG00000162378 MIM:618673; AllianceGenome:HGNC:25820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZYG11
    Summary
    Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZYG11B in Genome Data Viewer
    Location:
    1p32.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (52726453..52827336)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (52607957..52708870)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (53192125..53293008)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit S5 pseudogene 3 Neighboring gene RNA, 7SL, cytoplasmic 62, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 898 Neighboring gene RNA, U2 small nuclear 30, pseudogene Neighboring gene ribosomal protein S13 pseudogene 2 Neighboring gene RNA, U6 small nuclear 969, pseudogene Neighboring gene Sharpr-MPRA regulatory region 11599 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:53297677-53298444 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53301449-53302130 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53302131-53302812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53309013-53309606 Neighboring gene zyg-11 family member A, cell cycle regulator Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53334860-53335744 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53335745-53336627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53370741-53371532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53372219-53372718 Neighboring gene Sharpr-MPRA regulatory region 4702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:53377381-53377881 Neighboring gene enoyl-CoA hydratase domain containing 2 Neighboring gene translation machinery-associated protein 7-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:53387115-53387797

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13456

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul2-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein zyg-11 homolog B
    Names
    zyg-11 homolog B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024646.3NP_078922.1  protein zyg-11 homolog B

      See identical proteins and their annotated locations for NP_078922.1

      Status: VALIDATED

      Source sequence(s)
      AB051517, AC099784, AK296460, AL139255
      Consensus CDS
      CCDS30717.1
      UniProtKB/Swiss-Prot
      Q8N2X3, Q9C0D3, Q9H8L8
      UniProtKB/TrEMBL
      B3KTI5
      Related
      ENSP00000294353.6, ENST00000294353.7
      Conserved Domains (2) summary
      sd00034
      Location:188213
      LRR_AMN1; leucine-rich repeat [structural motif]
      NF033190
      Location:143248
      inl_like_NEAT_1; NEAT domain-containing leucine-rich repeat protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      52726453..52827336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002336.3XP_016857825.1  protein zyg-11 homolog B isoform X2

      UniProtKB/TrEMBL
      A8DPD7
      Related
      ENSP00000441315.1, ENST00000545132.5
      Conserved Domains (1) summary
      sd00034
      Location:188213
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. XM_006710898.5XP_006710961.1  protein zyg-11 homolog B isoform X1

      UniProtKB/TrEMBL
      B3KTI5
      Conserved Domains (3) summary
      cd00020
      Location:489607
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      cd00116
      Location:173295
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:184209
      LRR_AMN1; leucine-rich repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      52607957..52708870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338747.1XP_054194722.1  protein zyg-11 homolog B isoform X2

      UniProtKB/TrEMBL
      A8DPD7
    2. XM_054338746.1XP_054194721.1  protein zyg-11 homolog B isoform X1

      UniProtKB/TrEMBL
      B3KTI5