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    GPR22 G protein-coupled receptor 22 [ Homo sapiens (human) ]

    Gene ID: 2845, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR22provided by HGNC
    Official Full Name
    G protein-coupled receptor 22provided by HGNC
    Primary source
    HGNC:HGNC:4477
    See related
    Ensembl:ENSG00000172209 MIM:601910; AllianceGenome:HGNC:4477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene is a member of the G-protein coupled receptor 1 family and encodes a multi-pass membrane protein. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 6.9), brain (RPKM 4.8) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR22 in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (107470057..107477845)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (108786096..108792223)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (107110502..107116129)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901721 Neighboring gene component of oligomeric golgi complex 5 Neighboring gene MPRA-validated peak6677 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr7:107031303-107031825 Neighboring gene ribosomal protein L37a pseudogene 6 Neighboring gene MPRA-validated peak6680 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148389-107148890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:107148891-107149390 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:107204244-107204454 Neighboring gene DUS4L-BCAP29 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18539 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:107204943-107206142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26493 Neighboring gene uncharacterized LOC124901856 Neighboring gene dihydrouridine synthase 4 like Neighboring gene B cell receptor associated protein 29

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effects of RNA degradation on gene expression analysis of human postmortem tissues. Lee J, et al. FASEB J, 2005 Aug. PMID 15955843
    2. A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Kerkhof HJ, et al. Arthritis Rheum, 2010 Feb. PMID 20112360, Free PMC Article
    3. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction. Chang CC, et al. BMC Cardiovasc Disord, 2024 May 30. PMID 38816768, Free PMC Article
    4. Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor. Adams JW, et al. Am J Physiol Heart Circ Physiol, 2008 Aug. PMID 18539757
    5. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. O'Dowd BF, et al. Gene, 1997 Mar 10. PMID 9073069

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
      Title: Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction.
    2. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.
    3. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.
    4. Demonstrate GRR22 expression in human heart.
      Title: Myocardial expression, signaling, and function of GPR22: a protective role for an orphan G protein-coupled receptor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129847

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 22
    Names
    probable G-protein coupled receptor 22

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005295.3 → NP_005286.2  G-protein coupled receptor 22

      See identical proteins and their annotated locations for NP_005286.2

      Status: REVIEWED

      Source sequence(s)
      AC002381, AK122621, BC107128, DA519131, U66581
      Consensus CDS
      CCDS5744.1
      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9
      Related
      ENSP00000302676.4, ENST00000304402.6
      Conserved Domains (1) summary
      cd00637
      Location:44 → 370
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      107470057..107477845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420214.1 → XP_047276170.1  G-protein coupled receptor 22 isoform X1

      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9

    2. XM_011516056.4 → XP_011514358.1  G-protein coupled receptor 22 isoform X1

      See identical proteins and their annotated locations for XP_011514358.1

      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9
      Conserved Domains (1) summary
      cd00637
      Location:44 → 370
      7tm_classA_rhodopsin-like; rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_017852930.1 Reference GRCh38.p14 PATCHES

      Range
      315704..321332
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332133.1 → XP_054188108.1  G-protein coupled receptor 22 isoform X1

      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      108786096..108792223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357927.1 → XP_054213902.1  G-protein coupled receptor 22 isoform X1

      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9

    2. XM_054357926.1 → XP_054213901.1  G-protein coupled receptor 22 isoform X1

      UniProtKB/Swiss-Prot
      A4D0R8, O14554, Q99680
      UniProtKB/TrEMBL
      B3KV13, Q3KNS9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99680.2 GenPept UniProtKB/Swiss-Prot:Q99680

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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