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    KMT5B lysine methyltransferase 5B [ Homo sapiens (human) ]

    Gene ID: 51111, updated on 9-Dec-2024

    Summary

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    Official Symbol
    KMT5Bprovided by HGNC
    Official Full Name
    lysine methyltransferase 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:24283
    See related
    Ensembl:ENSG00000110066 MIM:610881; AllianceGenome:HGNC:24283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGI85; MRD51; CGI-85; SUV420H1
    Summary
    This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.1), endometrium (RPKM 8.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KMT5B in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68154863..68213648, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68158479..68217261, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67922330..67981115, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:67834020-67834520 Neighboring gene choline kinase alpha Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67850572-67850749 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67861600-67861729 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67870988-67871188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:67886638-67887154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5132 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3658 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67888828-67889593 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67889594-67890360 Neighboring gene CHKA divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr11:67907579-67907779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:67981441-67982143 Neighboring gene Sharpr-MPRA regulatory region 2086 Neighboring gene MPRA-validated peak1319 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68034746-68035945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68039550-68040404 Neighboring gene uncharacterized LOC105369363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3666 Neighboring gene chromosome 11 open reading frame 24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma. Kato H, et al. Cancer Sci, 2024 Feb. PMID 38082550, Free PMC Article
    2. Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1. Abini-Agbomson S, et al. Mol Cell, 2023 Aug 17. PMID 37595555
    3. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. Lin WY, et al. Nat Commun, 2021 Oct 29. PMID 34716350, Free PMC Article
    4. Histone Lysine Methylases and Demethylases in the Landscape of Human Developmental Disorders. Faundes V, et al. Am J Hum Genet, 2018 Jan 4. PMID 29276005, Free PMC Article
    5. Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity. Coe BP, et al. Nat Genet, 2019 Jan. PMID 30559488, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
      Title: Histone methyltransferase SUV420H1/KMT5B contributes to poor prognosis in hepatocellular carcinoma.
    2. Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
      Title: Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.
    3. Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
      Title: Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1.
    4. Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis.
      Title: Loss-of-function of KMT5B leads to neurodevelopmental disorder and impairs neuronal development and neurogenesis.
    5. Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.
      Title: Epigenetic Regulation by Suv4-20h1 in Cardiopulmonary Progenitor Cells Is Required to Prevent Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease.
    6. Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
      Title: Genome-wide association study identifies susceptibility loci for acute myeloid leukemia.
    7. Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
      Title: Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
    8. SUV420H1 is a protein lysine methyltransferase that introduces di- and trimethylation of H4K20 and is frequently mutated in human cancers. Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
      Title: Somatic Cancer Mutations in the SUV420H1 Protein Lysine Methyltransferase Modulate Its Catalytic Activity.
    9. epsilon-globin expression is regulated by SUV4-20h1.
      Title: ε-globin expression is regulated by SUV4-20h1.
    10. Altogether, these results reveal Suv4-20h-mediated histone H4K20 tri-methylation as a critical determinant in the selection of active replication initiation sites in heterochromatin regions of mammalian genomes.
      Title: Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual disability, autosomal dominant 51
    MedGen: C4540474 OMIM: 617788 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2023-06-13)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2023-06-13)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of suppressor of variegation 4-20 homolog 1 (SUV420H1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC703, MGC21161, MGC118906, MGC118909

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables S-adenosyl-L-methionine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4 methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables histone H4K20 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H4K20 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H4K20 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables histone H4K20 monomethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4K20me methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of isotype switching ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase KMT5B
    Names
    [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B
    [histone H4]-lysine20 N-methyltransferase KMT5B
    histone-lysine N-methyltransferase SUV420H1
    lysine (K)-specific methyltransferase 5B
    lysine N-methyltransferase 5B
    lysine-specific methyltransferase 5B
    su(var)4-20 homolog 1
    suppressor of variegation 4-20 homolog 1
    NP_001287836.1
    NP_001287837.1
    NP_001287838.1
    NP_001350495.1
    NP_001356353.1
    NP_001356354.1
    NP_001356355.1
    NP_001356356.1
    NP_001356357.1
    NP_001356358.1
    NP_001356359.1
    NP_001356360.1
    NP_001356361.1
    NP_001356362.1
    NP_057112.3
    NP_060105.3
    XP_005274092.2
    XP_005274093.2
    XP_006718644.1
    XP_011543394.1
    XP_024304338.1
    XP_047283027.1
    XP_047283028.1
    XP_047283029.1
    XP_054225022.1
    XP_054225023.1
    XP_054225024.1
    XP_054225025.1
    XP_054225026.1
    XP_054225027.1
    XP_054225028.1
    XP_054225029.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052873.1 RefSeqGene

      Range
      5477..63910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300907.1 → NP_001287836.1  histone-lysine N-methyltransferase KMT5B isoform 3

      See identical proteins and their annotated locations for NP_001287836.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate exon and uses a downstream start codon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AP002992, BC108304
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    2. NM_001300908.2 → NP_001287837.1  histone-lysine N-methyltransferase KMT5B isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate first exon and an alternate splice junction at the 5' end of an exon, and uses a downstream start codon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AK314336, AP002992, CR997801
      Conserved Domains (1) summary
      pfam00856
      Location:21 → 68
      SET; SET domain

    3. NM_001300909.2 → NP_001287838.1  histone-lysine N-methyltransferase KMT5B isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate first exon, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AK299201, AP002992, BC002522, CR997801, KC877427
      Consensus CDS
      CCDS76444.1
      UniProtKB/TrEMBL
      B7WNX0, B7Z5N2
      Related
      ENSP00000384724.2, ENST00000402185.6
      Conserved Domains (1) summary
      smart00317
      Location:180 → 291
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    4. NM_001363566.2 → NP_001350495.1  histone-lysine N-methyltransferase KMT5B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS86221.1
      UniProtKB/TrEMBL
      B5MCB3, B7Z5N2
      Related
      ENSP00000385005.1, ENST00000402789.5
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    5. NM_001369424.1 → NP_001356353.1  histone-lysine N-methyltransferase KMT5B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Related
      ENST00000700525.1
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    6. NM_001369425.1 → NP_001356354.1  histone-lysine N-methyltransferase KMT5B isoform 8

      Status: REVIEWED

      Source sequence(s)
      AP002992
      Consensus CDS
      CCDS91519.1
      UniProtKB/TrEMBL
      B7Z5N2, C9JFG1
      Related
      ENSP00000403233.2, ENST00000458496.2
      Conserved Domains (1) summary
      smart00317
      Location:132 → 243
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    7. NM_001369426.1 → NP_001356355.1  histone-lysine N-methyltransferase KMT5B isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS31623.1
      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    8. NM_001369427.1 → NP_001356356.1  histone-lysine N-methyltransferase KMT5B isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS44660.1
      UniProtKB/TrEMBL
      B7Z5N2
      Related
      ENSP00000385640.1, ENST00000405515.5
      Conserved Domains (1) summary
      smart00317
      Location:203 → 314
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    9. NM_001369428.1 → NP_001356357.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    10. NM_001369429.1 → NP_001356358.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Related
      ENSP00000515030.1, ENST00000700523.1
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    11. NM_001369430.1 → NP_001356359.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    12. NM_001369431.1 → NP_001356360.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    13. NM_001369432.1 → NP_001356361.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    14. NM_001369433.1 → NP_001356362.1  histone-lysine N-methyltransferase KMT5B isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427
      Consensus CDS
      CCDS91518.1
      UniProtKB/TrEMBL
      A0A8V8TQB9
      Conserved Domains (1) summary
      smart00317
      Location:31 → 142
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    15. NM_016028.4 → NP_057112.3  histone-lysine N-methyltransferase KMT5B isoform 2

      See identical proteins and their annotated locations for NP_057112.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' exon and utilizes an upstream stop codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC002522, BM152996
      Consensus CDS
      CCDS44660.1
      UniProtKB/TrEMBL
      B7Z5N2
      Related
      ENSP00000385965.2, ENST00000401547.6
      Conserved Domains (1) summary
      smart00317
      Location:203 → 314
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    16. NM_017635.5 → NP_060105.3  histone-lysine N-methyltransferase KMT5B isoform 1

      See identical proteins and their annotated locations for NP_060105.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AP002992, BC099714, BC108304
      Consensus CDS
      CCDS31623.1
      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
      Related
      ENSP00000305899.4, ENST00000304363.9
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    RNA

    1. NR_161378.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427

    2. NR_161379.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427

    3. NR_161380.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP002992, KC877427

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      68154863..68213648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427072.1 → XP_047283028.1  histone-lysine N-methyltransferase KMT5B isoform X4

    2. XM_011545092.4 → XP_011543394.1  histone-lysine N-methyltransferase KMT5B isoform X3

      UniProtKB/TrEMBL
      C9J6S5
      Related
      ENSP00000406377.2, ENST00000453170.6
      Conserved Domains (1) summary
      smart00317
      Location:132 → 243
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    3. XM_005274036.5 → XP_005274093.2  histone-lysine N-methyltransferase KMT5B isoform X2

      See identical proteins and their annotated locations for XP_005274093.2

      Conserved Domains (1) summary
      smart00317
      Location:180 → 291
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    4. XM_005274035.5 → XP_005274092.2  histone-lysine N-methyltransferase KMT5B isoform X1

      See identical proteins and their annotated locations for XP_005274092.2

      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393
      Conserved Domains (1) summary
      cd19184
      Location:192 → 335
      SET_KMT5B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5B (KMT5B) and similar proteins

    5. XM_006718581.2 → XP_006718644.1  histone-lysine N-methyltransferase KMT5B isoform X2

      See identical proteins and their annotated locations for XP_006718644.1

      Conserved Domains (1) summary
      smart00317
      Location:180 → 291
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

    6. XM_047427071.1 → XP_047283027.1  histone-lysine N-methyltransferase KMT5B isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

    7. XM_047427073.1 → XP_047283029.1  histone-lysine N-methyltransferase KMT5B isoform X5

    8. XM_024448570.2 → XP_024304338.1  histone-lysine N-methyltransferase KMT5B isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      68158479..68217261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369052.1 → XP_054225027.1  histone-lysine N-methyltransferase KMT5B isoform X4

    2. XM_054369051.1 → XP_054225026.1  histone-lysine N-methyltransferase KMT5B isoform X3

      UniProtKB/TrEMBL
      C9J6S5

    3. XM_054369049.1 → XP_054225024.1  histone-lysine N-methyltransferase KMT5B isoform X2

    4. XM_054369047.1 → XP_054225022.1  histone-lysine N-methyltransferase KMT5B isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

    5. XM_054369050.1 → XP_054225025.1  histone-lysine N-methyltransferase KMT5B isoform X2

    6. XM_054369048.1 → XP_054225023.1  histone-lysine N-methyltransferase KMT5B isoform X1

      UniProtKB/Swiss-Prot
      A0A0A0MT19, B7WNX7, Q3SX56, Q4FZB7, Q4V775, Q6P150, Q96E44, Q9BUL0, Q9H022, Q9H2K3, Q9NXV3, Q9Y393

    7. XM_054369053.1 → XP_054225028.1  histone-lysine N-methyltransferase KMT5B isoform X5

    8. XM_054369054.1 → XP_054225029.1  histone-lysine N-methyltransferase KMT5B isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZB7.5 GenPept UniProtKB/Swiss-Prot:Q4FZB7

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