Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacnb3provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit beta 3provided by RGD
Primary source: RGD:2248
See related: EnsemblRapid:ENSRNOG00000054274 AllianceGenome:RGD:2248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CACH3B
Summary: Enables calcium channel regulator activity; protein kinase binding activity; and voltage-gated calcium channel activity. Involved in several processes, including calcium ion transmembrane transport; regulation of nervous system process; and regulation of voltage-gated calcium channel activity. Located in apical plasma membrane. Part of L-type voltage-gated calcium channel complex. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 111.6), Lung (RPKM 35.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (131663810..131676085)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (129784799..129797074)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (140311120..140324902)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cavbeta3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic beta-Cells in a Cell-Autonomous Manner.
Title: Cavβ3 Regulates Ca(2+) Signaling and Insulin Expression in Pancreatic β-Cells in a Cell-Autonomous Manner.
Cavbeta(3) subunit at the spinal level represents an effective strategy for treating neuropathic pain
Title: Up-regulation of Cavβ3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain.
a model where high affinity binding of Ca(V)beta to the I-II linker of Ca(V)alpha1 largely accounts for Ca(V)beta-induced plasma membrane targeting of Ca(V)1.2
Title: Molecular determinants of the CaVbeta-induced plasma membrane targeting of the CaV1.2 channel.
neither Ca(V)beta3 nor Ca(V)beta4 are indispensable for hair cell Ca(2+) currents but contribute to the overall current properties
Title: Ba2+ currents in inner and outer hair cells of mice lacking the voltage-dependent Ca2+ channel subunits beta3 or beta4.
the beta structural core of CACNB2 and CACNB3 binds tightly to the alpha interaction domain (AID) motif, a sequence derived from the alpha1 subunit and the principal anchor site of beta
Title: The voltage-dependent calcium channel beta subunit contains two stable interacting domains.
beta3 can have a profound negative regulatory effect on N-type (and also R-type) calcium channels by causing a hyperpolarizing shift of the inactivation without affecting "ultra-slow" and "closed-state" inactivation properties.
Title: Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation.
docking of the RGK protein to the nucleotide-kinase domain of the Cavbeta subunit is reminiscent of the binding of GMP to guanylate kinase
Title: RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128224 (e-PCR)
- UniSTS:211532

PMC21756P1 (e-PCR)
- UniSTS:272067

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of detection of mechanical stimulus involved in sensory perception of touch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of high voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane hyperpolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane repolarization during action potential	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of L-type voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of L-type voltage-gated calcium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent L-type calcium channel subunit beta-3

Names: CAB3; Calcium channel subunit beta 3; calcium channel voltage-dependent subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012828.3 → NP_036960.1 voltage-dependent L-type calcium channel subunit beta-3

See identical proteins and their annotated locations for NP_036960.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P54287

UniProtKB/TrEMBL

A0A8I6GH08, A6KC95

Related

ENSRNOP00000087593.2, ENSRNOT00000097309.2

Conserved Domains (3) summary

cd12042
Location:58 → 125

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:176 → 356

Guanylate_kin; Guanylate kinase

pfam12052
Location:16 → 58

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

131663810..131676085

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257329.4 → XP_006257391.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X2

UniProtKB/TrEMBL

A0A8I6GH08

Related

ENSRNOP00000089211.2, ENSRNOT00000095350.2

Conserved Domains (3) summary

cd12042
Location:57 → 124

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:175 → 355

Guanylate_kin; Guanylate kinase

pfam12052
Location:15 → 57

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_039078460.2 → XP_038934388.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X4

Conserved Domains (3) summary

cd12042
Location:69 → 136

SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3

pfam00625
Location:187 → 253

Guanylate_kin; Guanylate kinase

pfam12052
Location:27 → 69

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
XM_017594673.3 → XP_017450162.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X1

UniProtKB/TrEMBL

A0A8I6A832, A0A8I6GH08
XM_063263026.1 → XP_063119096.1 voltage-dependent L-type calcium channel subunit beta-3 isoform X3