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    REXO1 RNA exonuclease 1 homolog [ Homo sapiens (human) ]

    Gene ID: 57455, updated on 27-Dec-2024

    Summary

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    Official Symbol
    REXO1provided by HGNC
    Official Full Name
    RNA exonuclease 1 homologprovided by HGNC
    Primary source
    HGNC:HGNC:24616
    See related
    Ensembl:ENSG00000079313 MIM:609614; AllianceGenome:HGNC:24616
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    REX1; ELOABP1; EloA-BP1; TCEB3BP1
    Summary
    Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Located in nuclear body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 12.3), spleen (RPKM 7.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See REXO1 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (1815248..1848483, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (1786564..1819798, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1815247..1848482, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene one cut homeobox 3 Neighboring gene uncharacterized LOC101928543 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13625 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1789295-1790117 Neighboring gene ATPase phospholipid transporting 8B3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1795609-1796421 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1796422-1797233 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1799861-1800031 Neighboring gene MPRA-validated peak3225 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1811783-1812528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13626 Neighboring gene uncharacterized LOC100288123 Neighboring gene microRNA 1909 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1827207-1827342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1828468-1828968 Neighboring gene MPRA-validated peak3226 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1834459-1835425 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1835426-1836391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1837058-1838052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13628 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1853940-1854496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1854497-1855054 Neighboring gene Sharpr-MPRA regulatory region 8340 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13629 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9747 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1861121-1862006 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9749 Neighboring gene KLF16 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9751 Neighboring gene KLF transcription factor 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1865114-1865668 Neighboring gene KLF16-I enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:1873541-1874256 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:1875445-1876145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1876146-1876845 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:1876846-1877546 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:1884760-1884907 Neighboring gene abhydrolase domain containing 17A, depalmitoylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Demarcation of stable subpopulations within the pluripotent hESC compartment. Bhatia S, et al. PLoS One, 2013. PMID 23437358, Free PMC Article
    2. REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells. Bhandari DR, et al. PLoS One, 2010 May 5. PMID 20463961, Free PMC Article
    3. RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation. Gontan C, et al. Nature, 2012 Apr 29. PMID 22596162
    4. Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain. Tamura K, et al. Biochem Biophys Res Commun, 2003 Sep 12. PMID 12943681
    5. Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity. Wang Y, et al. J Biol Chem, 2021 Jan-Jun. PMID 33298525, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of REX1 expression demarcates stable, OCT4-positive lineage pluripotent human embryonic stem cells.
      Title: Demarcation of stable subpopulations within the pluripotent hESC compartment.
    2. These findings showed that REX1 regulates the proliferation/differentiation of human mesenchymal stem cells through the suppression of p38 MAPK signaling via the direct suppression of MKK3.
      Title: REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells.
    3. cloning and characterization of a novel human exonuclease domain-containing protein, Elongin A-binding protein 1; it is capable of binding not only the NH(2)-terminal approximately 120 amino acid region of Elongin A, but also that of SII
      Title: Identification of EloA-BP1, a novel Elongin A binding protein with an exonuclease homology domain.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1138

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease 1 homolog
    Names
    REX1, RNA exonuclease 1 homolog
    elongin-A-binding protein 1
    transcription elongation factor B polypeptide 3-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020695.4 → NP_065746.3  RNA exonuclease 1 homolog

      See identical proteins and their annotated locations for NP_065746.3

      Status: VALIDATED

      Source sequence(s)
      AC012615, BC032244
      Consensus CDS
      CCDS32866.1
      UniProtKB/Swiss-Prot
      Q8N1G1, Q9ULT2
      Related
      ENSP00000170168.3, ENST00000170168.9
      Conserved Domains (2) summary
      cd06145
      Location:1061 → 1209
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:802 → 962
      EloA-BP1; ElonginA binding-protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      1815248..1848483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027028.2 → XP_016882517.1  RNA exonuclease 1 homolog isoform X2

    2. XM_017027029.2 → XP_016882518.1  RNA exonuclease 1 homolog isoform X4

    3. XM_011528144.2 → XP_011526446.1  RNA exonuclease 1 homolog isoform X1

      Conserved Domains (2) summary
      cd06145
      Location:1070 → 1203
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:802 → 962
      EloA-BP1; ElonginA binding-protein 1

    4. XM_011528146.3 → XP_011526448.1  RNA exonuclease 1 homolog isoform X3

      Conserved Domains (2) summary
      cd06145
      Location:1035 → 1168
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
      pfam15870
      Location:767 → 927
      EloA-BP1; ElonginA binding-protein 1

    5. XM_047439121.1 → XP_047295077.1  RNA exonuclease 1 homolog isoform X6

    6. XM_047439120.1 → XP_047295076.1  RNA exonuclease 1 homolog isoform X5

    7. XM_047439122.1 → XP_047295078.1  RNA exonuclease 1 homolog isoform X7

    8. XM_047439123.1 → XP_047295079.1  RNA exonuclease 1 homolog isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      1786564..1819798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321525.1 → XP_054177500.1  RNA exonuclease 1 homolog isoform X2

    2. XM_054321527.1 → XP_054177502.1  RNA exonuclease 1 homolog isoform X4

    3. XM_054321524.1 → XP_054177499.1  RNA exonuclease 1 homolog isoform X1

    4. XM_054321526.1 → XP_054177501.1  RNA exonuclease 1 homolog isoform X3

    5. XM_054321529.1 → XP_054177504.1  RNA exonuclease 1 homolog isoform X6

    6. XM_054321528.1 → XP_054177503.1  RNA exonuclease 1 homolog isoform X5

    7. XM_054321530.1 → XP_054177505.1  RNA exonuclease 1 homolog isoform X7

    8. XM_054321531.1 → XP_054177506.1  RNA exonuclease 1 homolog isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N1G1.3 GenPept UniProtKB/Swiss-Prot:Q8N1G1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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