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    Hint3 histidine triad nucleotide binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hint3provided by MGI
    Official Full Name
    histidine triad nucleotide binding protein 3provided by MGI
    Primary source
    MGI:MGI:1914097
    See related
    Ensembl:ENSMUSG00000019791 AllianceGenome:MGI:1914097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HINT4; HINT-3; HINT-4; 0610010I17Rik
    Summary
    Predicted to enable adenosine 5'-monophosphoramidase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in embryo; liver; lung; metanephros; and spleen. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 4.5), heart adult (RPKM 4.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hint3 in Genome Data Viewer
    Location:
    10 A4; 10 17.1 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (30479191..30499526, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (30603195..30623530, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22623 Neighboring gene tRNA methyltransferase 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30320514-30320623 Neighboring gene STARR-positive B cell enhancer ABC_E6828 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:30338273-30338456 Neighboring gene predicted gene, 20300 Neighboring gene STARR-seq mESC enhancer starr_26197 Neighboring gene STARR-seq mESC enhancer starr_26199 Neighboring gene nuclear receptor coactivator 7 Neighboring gene STARR-seq mESC enhancer starr_26200 Neighboring gene STARR-positive B cell enhancer ABC_E5123 Neighboring gene STARR-seq mESC enhancer starr_26202 Neighboring gene STARR-positive B cell enhancer ABC_E8861 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene nuclear encoded tRNA glutamic acid 9 (anticodon CTC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histidine triad protein Hint is not required for murine development or Cdk7 function. Korsisaari N, et al. Mol Cell Biol, 2003 Jun. PMID 12748294, Free PMC Article
    2. The Axonal Motor Neuropathy-Related HINT1 Protein Is a Zinc- and Calmodulin-Regulated Cysteine SUMO Protease. Cortés-Montero E, et al. Antioxid Redox Signal, 2019 Sep 1. PMID 31088288, Free PMC Article
    3. PEG3 control on the mammalian MSL complex. Ye A, et al. PLoS One, 2017. PMID 28609438, Free PMC Article
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenosine 5'-monophosphoramidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables adenosine 5'-monophosphoramidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    adenosine 5'-monophosphoramidase HINT3
    Names
    histidine triad protein 4
    NP_080074.1
    XP_006512886.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025798.3 → NP_080074.1  adenosine 5'-monophosphoramidase HINT3

      See identical proteins and their annotated locations for NP_080074.1

      Status: PROVISIONAL

      Source sequence(s)
      AK027974
      Consensus CDS
      CCDS23764.1
      UniProtKB/Swiss-Prot
      Q9CPS6
      UniProtKB/TrEMBL
      F8WH96
      Related
      ENSMUSP00000125552.2, ENSMUST00000161074.8
      Conserved Domains (1) summary
      cd01278
      Location:30 → 133
      aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      30479191..30499526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512823.3 → XP_006512886.1  adenosine 5'-monophosphoramidase HINT3 isoform X1

      Conserved Domains (1) summary
      cd01278
      Location:30 → 168
      aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPS6.1 GenPept UniProtKB/Swiss-Prot:Q9CPS6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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