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    Nek10 NIMA (never in mitosis gene a)- related kinase 10 [ Mus musculus (house mouse) ]

    Gene ID: 674895, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Nek10provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)- related kinase 10provided by MGI
    Primary source
    MGI:MGI:2685128
    See related
    Ensembl:ENSMUSG00000042567 AllianceGenome:MGI:2685128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm282
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including mucociliary clearance; positive regulation of protein phosphorylation; and regulation of ERK1 and ERK2 cascade. Predicted to be located in extracellular region. Predicted to be part of protein kinase complex. Is expressed in brain and female reproductive system. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Orthologous to human NEK10 (NIMA related kinase 10). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Nek10 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (7457704..7666183, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (14803580..15012059)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31517 Neighboring gene STARR-seq mESC enhancer starr_36001 Neighboring gene predicted gene, 18142 Neighboring gene predicted gene, 46441 Neighboring gene STARR-seq mESC enhancer starr_36000 Neighboring gene STARR-seq mESC enhancer starr_35999 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 7 Neighboring gene STARR-seq mESC enhancer starr_35997 Neighboring gene STARR-positive B cell enhancer ABC_E749 Neighboring gene predicted gene, 52165

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation. Moniz LS, et al. Mol Cell Biol, 2011 Jan. PMID 20956560, Free PMC Article
    2. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. You L, et al. J Biol Chem, 2015 May 1. PMID 25773539, Free PMC Article
    3. Lineage-specific biology revealed by a finished genome assembly of the mouse. Church DM, et al. PLoS Biol, 2009 May 5. PMID 19468303, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mucociliary clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mucociliary clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein kinase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase Nek10
    Names
    never in mitosis A-related kinase 10
    nimA-related protein kinase 10
    NP_001182158.1
    NP_001381921.1
    XP_006518155.1
    XP_006518159.1
    XP_011243073.1
    XP_017171654.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195229.2 → NP_001182158.1  serine/threonine-protein kinase Nek10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC117608, AC129580
      Consensus CDS
      CCDS56937.1
      UniProtKB/Swiss-Prot
      Q3UGM2
      UniProtKB/TrEMBL
      K3W4R8
      Related
      ENSMUSP00000153142.2, ENSMUST00000224491.2
      Conserved Domains (2) summary
      smart00220
      Location:519 → 779
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    2. NM_001394992.1 → NP_001381921.1  serine/threonine-protein kinase Nek10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117608, AC129580
      UniProtKB/Swiss-Prot
      Q3UGM2
      Related
      ENSMUSP00000108250.3, ENSMUST00000112631.9
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      7457704..7666183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518092.2 → XP_006518155.1  serine/threonine-protein kinase Nek10 isoform X1

      See identical proteins and their annotated locations for XP_006518155.1

      UniProtKB/Swiss-Prot
      Q3UGM2
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    2. XM_011244771.1 → XP_011243073.1  serine/threonine-protein kinase Nek10 isoform X1

      See identical proteins and their annotated locations for XP_011243073.1

      UniProtKB/Swiss-Prot
      Q3UGM2
      Conserved Domains (1) summary
      cd08528
      Location:518 → 785
      STKc_Nek10; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10

    3. XM_017316165.1 → XP_017171654.1  serine/threonine-protein kinase Nek10 isoform X3

      Conserved Domains (1) summary
      cl21453
      Location:19 → 106
      PKc_like; Protein Kinases, catalytic domain

    4. XM_006518096.5 → XP_006518159.1  serine/threonine-protein kinase Nek10 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:518 → 672
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_382965.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001034865.3: Suppressed sequence

      Description
      NM_001034865.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UGM2.2 GenPept UniProtKB/Swiss-Prot:Q3UGM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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