Filip1l filamin A interacting protein 1-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Filip1lprovided by MGI
Official Full Name: filamin A interacting protein 1-likeprovided by MGI
Primary source: MGI:MGI:1925999
See related: Ensembl:ENSMUSG00000043336 AllianceGenome:MGI:1925999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Doc1; 4631422O05Rik
Summary: Predicted to be involved in protein localization to actin cytoskeleton. Predicted to be located in cytoplasm; membrane; and nucleus. Predicted to be active in actin cytoskeleton. Is expressed in pectoral girdle and thoracic body wall musculature. Orthologous to human FILIP1L (filamin A interacting protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 18.6), limb E14.5 (RPKM 7.5) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.1; 16 34.22 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (57173376..57393167)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (57353277..57572804)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
Title: Smoking-associated Downregulation of FILIP1L Enhances Lung Adenocarcinoma Progression Through Mucin Production, Inflammation, and Fibrosis.
FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
Title: FILIP1L Loss Is a Driver of Aggressive Mucinous Colorectal Adenocarcinoma and Mediates Cytokinesis Defects through PFDN1.
GPBP directs myofibril formation through interaction with intracellular downstream effector 130-kDa GPBP-interacting protein
Title: Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D16Mit64 (e-PCR), detects polymorphism
- UniSTS:127898

DOC1_9246 (e-PCR)
- UniSTS:468384

FILIP1L (e-PCR)
- UniSTS:505560

MHAa38e10.seq (e-PCR)
- UniSTS:125171

GDB:306049 (e-PCR)
- UniSTS:156414

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindgut development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteasomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in centrosome	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: filamin A-interacting protein 1-like

Names: downregulated in ovarian cancer 1-like; protein down-regulated in ovarian cancer 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040397.5 → NP_001035487.2 filamin A-interacting protein 1-like isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC144776, CT025521, CT030226

Consensus CDS

CCDS37366.2

UniProtKB/Swiss-Prot

B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0

UniProtKB/TrEMBL

E0CYH7

Related

ENSMUSP00000124179.2, ENSMUST00000159816.8

Conserved Domains (3) summary

COG0419
Location:85 → 678

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR02168
Location:539 → 842

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09727
Location:64 → 246

CortBP2; Cortactin-binding protein-2
NM_001177871.1 → NP_001171342.1 filamin A-interacting protein 1-like isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC144776, AK019472

Consensus CDS

CCDS49877.1

UniProtKB/TrEMBL

E0CYM1

Related

ENSMUSP00000124069.2, ENSMUST00000159414.2

Conserved Domains (5) summary

COG1340
Location:87 → 360

COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]

pfam00901
Location:189 → 302

Orbi_VP5; Orbivirus outer capsid protein VP5

pfam06009
Location:53 → 139

Laminin_II; Laminin Domain II

pfam17061
Location:668 → 890

PARM; PARM

cl03075
Location:380 → 431

GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

57173376..57393167

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249333.2 → XP_030105193.1 filamin A-interacting protein 1-like isoform X1

UniProtKB/Swiss-Prot

B2ZAA3, B3GM33, Q05CK4, Q3UIY5, Q4G0B9, Q6P6L0

Conserved Domains (3) summary

COG1196
Location:138 → 502

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02169
Location:4 → 220

SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

pfam17061
Location:722 → 944

PARM