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    Klhdc7a kelch domain containing 7A [ Mus musculus (house mouse) ]

    Gene ID: 242721, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klhdc7aprovided by MGI
    Official Full Name
    kelch domain containing 7Aprovided by MGI
    Primary source
    MGI:MGI:2444612
    See related
    Ensembl:ENSMUSG00000078234 AllianceGenome:MGI:2444612
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230308G19Rik
    Summary
    Predicted to be located in membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human KLHDC7A (kelch domain containing 7A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Klhdc7a in Genome Data Viewer
    Location:
    4 D3; 4 71.03 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (139689484..139695337, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (139962173..139968026, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene paired box 7 Neighboring gene predicted gene, 46873 Neighboring gene STARR-seq mESC enhancer starr_11842 Neighboring gene RIKEN cDNA 4933427I22 gene Neighboring gene predicted gene 1667 Neighboring gene STARR-seq mESC enhancer starr_11844 Neighboring gene STARR-seq mESC enhancer starr_11846 Neighboring gene microRNA 2139 Neighboring gene STARR-seq mESC enhancer starr_11847 Neighboring gene immunoglobulin superfamily, member 21 Neighboring gene VISTA enhancer mm1730 Neighboring gene predicted gene, 52685 Neighboring gene STARR-seq mESC enhancer starr_11853 Neighboring gene STARR-seq mESC enhancer starr_11854 Neighboring gene predicted gene 13029

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kelch domain-containing protein 7A
    Names
    novel kelch domain containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173427.2 → NP_775603.2  kelch domain-containing protein 7A

      See identical proteins and their annotated locations for NP_775603.2

      Status: VALIDATED

      Source sequence(s)
      AL844480, AW124675
      Consensus CDS
      CCDS38935.1
      UniProtKB/Swiss-Prot
      A2APT9, Q80SV4, Q8C706
      UniProtKB/TrEMBL
      Q8C7K3
      Related
      ENSMUSP00000100648.3, ENSMUST00000105031.4
      Conserved Domains (4) summary
      smart00612
      Location:538 → 585
      Kelch; Kelch domain
      sd00038
      Location:527 → 571
      Kelch; KELCH repeat [structural motif]
      pfam01344
      Location:574 → 615
      Kelch_1; Kelch motif
      cl06652
      Location:426 → 466
      BACK_like; BTB-And-C-terminal-Kelch (BACK) domain and similar domains

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      139689484..139695337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2APT9.3 GenPept UniProtKB/Swiss-Prot:A2APT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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