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    Tpte transmembrane phosphatase with tensin homology [ Mus musculus (house mouse) ]

    Gene ID: 234129, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tpteprovided by MGI
    Official Full Name
    transmembrane phosphatase with tensin homologyprovided by MGI
    Primary source
    MGI:MGI:2446460
    See related
    Ensembl:ENSMUSG00000031481 AllianceGenome:MGI:2446460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vsp; Pten2
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in brain; eye; future spinal cord; surface ectoderm; and testis. Orthologous to several human genes including TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 1.2), kidney adult (RPKM 0.2) and 6 other tissues See more
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    Genomic context

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    See Tpte in Genome Data Viewer
    Location:
    8 A2; 8 11.2 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22773457..22861432)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (22283315..22371418)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 36 Neighboring gene ribosomal protein L30, pseudogene 2 Neighboring gene thrombospondin, type I, domain 1 Neighboring gene predicted gene, 46035 Neighboring gene solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 Neighboring gene RIKEN cDNA 1810012K16 gene Neighboring gene STARR-positive B cell enhancer ABC_E6625

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase. Kawai T, et al. Nat Commun, 2024 Aug 24. PMID 39181879, Free PMC Article
    2. Polarized PtdIns(4,5)P(2) distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility. Kawai T, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31776261, Free PMC Article
    3. A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. Mishra RR, et al. PLoS One, 2011. PMID 22164291, Free PMC Article
    4. Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE. Lu S, et al. Mol Med Rep, 2017 Jul. PMID 28498403
    5. The TPTE gene family: cellular expression, subcellular localization and alternative splicing. Tapparel C, et al. Gene, 2003 Dec 24. PMID 14659893

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mmumiR449a may ameliorate neuropathic pain by decreasing the activity of the channel proteins TRPA1 and KCNMA1 and increasing the levels of TPTE.
      Title: Mus musculus-microRNA-449a ameliorates neuropathic pain by decreasing the level of KCNMA1 and TRPA1, and increasing the level of TPTE.
    2. the TPIP splice-variant (TPIP-C2) mRNA is expressed in human and mouse tissues and strongly inhibits cell growth in HeLa cells
      Title: A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130293

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane phosphatase with tensin homology
    NP_954866.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199257.3 → NP_954866.2  transmembrane phosphatase with tensin homology

      See identical proteins and their annotated locations for NP_954866.2

      Status: VALIDATED

      Source sequence(s)
      AC121933, AC140326
      Consensus CDS
      CCDS22173.1
      UniProtKB/TrEMBL
      G5E8H5, Q3KNE1
      Related
      ENSMUSP00000076435.2, ENSMUST00000077194.2
      Conserved Domains (2) summary
      smart00404
      Location:413 → 478
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
      pfam10409
      Location:529 → 663
      PTEN_C2; C2 domain of PTEN tumour-suppressor protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22773457..22861432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181851.3: Suppressed sequence

      Description
      NM_181851.3: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_199258.1: Suppressed sequence

      Description
      NM_199258.1: This RefSeq was permanently suppressed because it contains the wrong CDS.
    Nucleotide Protein Strain
    Heading Accession and Version

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