Nelfcd negative elongation factor complex member C/D, Th1l [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nelfcdprovided by MGI
Official Full Name: negative elongation factor complex member C/D, Th1lprovided by MGI
Primary source: MGI:MGI:1926424
See related: Ensembl:ENSMUSG00000016253 AllianceGenome:MGI:1926424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Th1; Th1l; NELF-D; 2410003I03Rik
Summary: Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of NELF complex. Is expressed in several structures, including 1st branchial arch; early embryo; limb; main olfactory bulb; and maxillary process. Orthologous to human NELFCD (negative elongation factor complex member C/D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 31.1), limb E14.5 (RPKM 29.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 97.93 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (174257623..174269298)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174415804..174427505)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that TH1 is a novel regulator to control the duration and magnitude of androgen signal transduction and might be directly involved in androgen-related developmental, physiological, and pathological processes.
Title: Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation.
results indicated that Nrf2 protects against the development of pulmonary fibrosis by regulating the cellular redox level and lung Th1/Th2 balance.
Title: Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance.
The gene expression of TH1 in mouse testis and changes of TH1 protein during postnatal development, were analyzed.
Title: Expression and distribution of trihydrophobin 1 in postnatal developing mouse testis.
TH1 interacts with PAK1 and specifically restricts the activation of MAPK modules through the upstream region of the MAPK pathway, thereby influencing cell migration.
Title: Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration.
In conclusion, our data suggest that RelB is an important target for morphine modulation of proinflammatory and Th1 cytokines. They also indicate that morphine uses multiple intracellular pathways to exert its generalized immunosuppression.
Title: Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125743 (e-PCR)
- UniSTS:142374

AI787083 (e-PCR)
- UniSTS:178788

RH136301 (e-PCR)
- UniSTS:210293

RH126244 (e-PCR)
- UniSTS:162952

RH124643 (e-PCR)
- UniSTS:161465

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NELF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NELF complex	ISO Inferred from Sequence Orthology more info
part_of NELF complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: negative elongation factor D

Names: TH1 homolog; TH1-like homolog; TH1-like protein; trihydrophobin 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020580.4 → NP_065605.3 negative elongation factor D

Status: VALIDATED

Source sequence(s)

AL844534

Consensus CDS

CCDS38358.1

Related

ENSMUSP00000104703.2, ENSMUST00000109075.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

174257623..174269298

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006499946.4 → XP_006500009.1 negative elongation factor D isoform X1

UniProtKB/Swiss-Prot

A2AQ05, Q922L6, Q9QXC8, Q9QXC9, Q9QXD0

Conserved Domains (1) summary

pfam04858
Location:1 → 530

TH1; TH1 protein