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    Trank1 tetratricopeptide repeat and ankyrin repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 320429, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Trank1provided by MGI
    Official Full Name
    tetratricopeptide repeat and ankyrin repeat containing 1provided by MGI
    Primary source
    MGI:MGI:1341834
    See related
    Ensembl:ENSMUSG00000062296 AllianceGenome:MGI:1341834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lba1; Gm187; A230061D21Rik; C030048J01Rik
    Summary
    Is expressed in adrenal cortex; central nervous system; frenulum; lung; and seminiferous cord. Orthologous to human TRANK1 (tetratricopeptide repeat and ankyrin repeat containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 42.3), cortex adult (RPKM 41.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trank1 in Genome Data Viewer
    Location:
    9 F3; 9 60.95 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (111140351..111224843)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (111311283..111395775)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51692 Neighboring gene mutL homolog 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:111177746-111177899 Neighboring gene EPM2A interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_25291 Neighboring gene doublecortin-like kinase 3 Neighboring gene STARR-seq mESC enhancer starr_25292 Neighboring gene STARR-seq mESC enhancer starr_25295 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and cloning of a brain autoantigen in neuro-behavioral SLE. Moore PM, et al. J Neuroimmunol, 1998 Mar 1. PMID 9585807
    2. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. McClelland KS, et al. Biol Reprod, 2015 Jun. PMID 25855264
    3. Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures. Wang N, et al. Neuron, 2022 Oct 19. PMID 36265442, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    TPR and ankyrin repeat-containing protein 1
    Names
    lupus brain antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164659.1 → NP_001158131.1  TPR and ankyrin repeat-containing protein 1

      See identical proteins and their annotated locations for NP_001158131.1

      Status: VALIDATED

      Source sequence(s)
      AC113495, AK079552, BC086653, BY728326
      Consensus CDS
      CCDS52942.1
      UniProtKB/Swiss-Prot
      Q5RJH5, Q6ZQD5, Q8BV79
      Related
      ENSMUSP00000077697.4, ENSMUST00000078626.8
      Conserved Domains (5) summary
      cd00204
      Location:542 → 664
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      pfam12796
      Location:543 → 656
      Ank_2; Ankyrin repeats (3 copies)
      pfam13414
      Location:144 → 207
      TPR_11; TPR repeat
      sd00045
      Location:542 → 569
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      111140351..111224843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512160.4 → XP_006512223.1  TPR and ankyrin repeat-containing protein 1 isoform X1

      Conserved Domains (5) summary
      PHA03381
      Location:22 → 136
      PHA03381; tegument protein VP22; Provisional
      PHA03095
      Location:317 → 432
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:498 → 681
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      sd00045
      Location:552 → 579
      ANK; ANK repeat [structural motif]

    2. XM_017313432.2 → XP_017168921.1  TPR and ankyrin repeat-containing protein 1 isoform X3

      Conserved Domains (5) summary
      PHA03381
      Location:22 → 136
      PHA03381; tegument protein VP22; Provisional
      PHA03095
      Location:316 → 431
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:497 → 680
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      sd00045
      Location:551 → 578
      ANK; ANK repeat [structural motif]

    3. XM_006512161.4 → XP_006512224.1  TPR and ankyrin repeat-containing protein 1 isoform X2

      Conserved Domains (5) summary
      PHA03381
      Location:22 → 136
      PHA03381; tegument protein VP22; Provisional
      PHA03095
      Location:316 → 431
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:497 → 680
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      sd00045
      Location:551 → 578
      ANK; ANK repeat [structural motif]

    4. XM_006512162.4 → XP_006512225.1  TPR and ankyrin repeat-containing protein 1 isoform X4

      Conserved Domains (5) summary
      PHA03381
      Location:22 → 136
      PHA03381; tegument protein VP22; Provisional
      PHA03095
      Location:308 → 423
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:489 → 672
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      sd00045
      Location:543 → 570
      ANK; ANK repeat [structural motif]

    5. XM_006512164.4 → XP_006512227.1  TPR and ankyrin repeat-containing protein 1 isoform X6

      Conserved Domains (6) summary
      PHA03381
      Location:22 → 136
      PHA03381; tegument protein VP22; Provisional
      COG0666
      Location:498 → 681
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      TIGR02785
      Location:1472 → 1559
      addA_Gpos; helicase-exonuclease AddAB, AddA subunit, Firmicutes type
      sd00006
      Location:144 → 172
      TPR; TPR repeat [structural motif]
      sd00045
      Location:552 → 579
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:322 → 417
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_006512163.5 → XP_006512226.1  TPR and ankyrin repeat-containing protein 1 isoform X5

      Conserved Domains (4) summary
      PHA03095
      Location:209 → 324
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:390 → 573
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:36 → 64
      TPR; TPR repeat [structural motif]
      sd00045
      Location:444 → 471
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_379871.4 RNA Sequence

    2. XR_004935454.1 RNA Sequence

    3. XR_379872.3 RNA Sequence

    4. XR_003947933.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BV79.3 GenPept UniProtKB/Swiss-Prot:Q8BV79

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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