Gja4 gap junction protein, alpha 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gja4provided by MGI
Official Full Name: gap junction protein, alpha 4provided by MGI
Primary source: MGI:MGI:95715
See related: Ensembl:ENSMUSG00000050234 AllianceGenome:MGI:95715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cx37; Cnx37; Cxnh1; Gja-4
Summary: Predicted to enable gap junction channel activity. Acts upstream of or within blood vessel development. Predicted to be located in gap junction. Predicted to be part of connexin complex. Is expressed in several structures, including central nervous system; eye; gonad; heart; and vascular system. Human ortholog(s) of this gene implicated in coronary artery disease and myocardial infarction. Orthologous to human GJA4 (gap junction protein alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in lung adult (RPKM 80.0), ovary adult (RPKM 28.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 61.47 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (127205213..127207832, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (127311420..127314039, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas.
Title: Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas.
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.
Title: Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest.
Connexin 37 Regulates the Kv1.3 Pathway and Promotes the Development of Atherosclerosis.
Title: Connexin 37 Regulates the Kv1.3 Pathway and Promotes the Development of Atherosclerosis.
Targeting Endothelial Connexin37 Reduces Angiogenesis and Decreases Tumor Growth.
Title: Targeting Endothelial Connexin37 Reduces Angiogenesis and Decreases Tumor Growth.
Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
Title: Alteration of Cx37, Cx40, Cx43, Cx45, Panx1, and Renin Expression Patterns in Postnatal Kidneys of Dab1-/- (yotari) Mice.
Genetic deletion of connexin 37 causes polyuria and polydipsia.
Title: Genetic deletion of connexin 37 causes polyuria and polydipsia.
These findings provide evidence that Cx37 selectively influences Ang II signaling, mostly via a modulation of the expression of the Ang II type 2 receptor.
Title: Connexin37-Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II -Mediated Hypertension.
Shear stress in the physiological range prevents inward remodeling in cultured arteries due to chronic constriction through an NO-, and specifically an eNOS-dependent, mechanism and increases connexin 37 expression.
Title: Shear Stress Attenuates Inward Remodeling in Cultured Mouse Thoracodorsal Arteries in an eNOS-Dependent, but Not Hemodynamic Manner, and Increases Cx37 Expression.
Diet-induced hyperhomocysteinemia enhanced myoendothelial feedback, and increased Cx37 and IK1 expression may contribute. nNOS or iNOS did not upregulate to compensate for decreased eNOS, and they had little involvement in vasomotor function.
Title: Increased myoendothelial feedback is associated with increased connexin37 and IK1 channel expression in mesenteric arteries of diet-induced hyperhomocysteinemic mice.
The presence of Cx37 in the media layer of injured arteries restrains vascular smooth muscle cell proliferation and limits the development of intimal hyperplasia, presumably by interfering with the pro-proliferative effect of Cx43 and the Akt pathway.
Title: Connexin37 reduces smooth muscle cell proliferation and intimal hyperplasia in a mouse model of carotid artery ligation.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1) 1 citation

General gene information

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Markers

UniSTS:226049 (e-PCR)
- UniSTS:226049

Gja4 (e-PCR), detects polymorphism
- UniSTS:226049

NoName (e-PCR)
- UniSTS:235032

Gja4 (e-PCR), detects polymorphism
- UniSTS:498238

X57971 (e-PCR)
- UniSTS:159295

AW558810 (e-PCR)
- UniSTS:179068

Gja4 (e-PCR), detects polymorphism
- UniSTS:496768

RH136385 (e-PCR)
- UniSTS:210375

Gja4 (e-PCR), detects polymorphism
- UniSTS:166616

PMC197251P2 (e-PCR)
- UniSTS:271851

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gap junction channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in endothelium development	IEA Inferred from Electronic Annotation more info
involved_in response to pain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of connexin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of connexin complex	IEA Inferred from Electronic Annotation more info
part_of connexin complex	ISO Inferred from Sequence Orthology more info
located_in gap junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gap junction alpha-4 protein

Names: connexin h1; connexin-37; gap junction membrane channel protein alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.