Adal adenosine deaminase-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adalprovided by MGI
Official Full Name: adenosine deaminase-likeprovided by MGI
Primary source: MGI:MGI:1923144
See related: Ensembl:ENSMUSG00000027259 AllianceGenome:MGI:1923144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mapda; 4930578F03Rik
Summary: Predicted to enable adenosine deaminase activity. Acts upstream of or within response to alcohol. Orthologous to human MAPDA (N6-Methyl-AMP deaminase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 7.4), CNS E14 (RPKM 5.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 60.37 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (120970525..120989921)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (121140044..121159440)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

genetically protective factor against alcohol consumption
Title: Genetic Variability in Adenosine Deaminase-Like Contributes to Variation in Alcohol Preference in Mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N6-methyl-AMP deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenosine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to alcohol	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: N6-Methyl-AMP deaminase; adenosine deaminase-like protein

NP_001277740.1

EC 3.5.4.-

NP_001277741.1

EC 3.5.4.-

NP_001342677.1

EC 3.5.4.-

NP_083751.1

EC 3.5.4.-

XP_006500414.1

EC 3.5.4.-

XP_006500415.1

EC 3.5.4.-

XP_006500416.1

EC 3.5.4.-

XP_006500422.1

EC 3.5.4.-

XP_006500423.1

EC 3.5.4.-

XP_011238139.1

EC 3.5.4.-

XP_030108038.1

EC 3.5.4.-

XP_030108039.1

EC 3.5.4.-

XP_030108040.1

EC 3.5.4.-

XP_030108041.1

EC 3.5.4.-

XP_030108042.1

EC 3.5.4.-

XP_030108043.1

EC 3.5.4.-

XP_036018550.1

EC 3.5.4.-

XP_036018551.1

EC 3.5.4.-

XP_036018552.1

EC 3.5.4.-

XP_036018553.1

EC 3.5.4.-

XP_036018554.1

EC 3.5.4.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290811.1 → NP_001277740.1 N6-Methyl-AMP deaminase isoform b

See identical proteins and their annotated locations for NP_001277740.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to variant 1.

Source sequence(s)

AK016299, AK048809, AK049697

Consensus CDS

CCDS71121.1

UniProtKB/Swiss-Prot

Q80SY6

Related

ENSMUSP00000028702.4, ENSMUST00000028702.10

Conserved Domains (1) summary

cd00443
Location:1 → 277

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
NM_001290812.1 → NP_001277741.1 N6-Methyl-AMP deaminase isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains alternate 5' exon structure, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it also includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to variant 1.

Source sequence(s)

AK039677, AK048809, AK049697

Consensus CDS

CCDS79836.1

UniProtKB/TrEMBL

Z4YL50

Related

ENSMUSP00000106293.2, ENSMUST00000110665.8

Conserved Domains (1) summary

cl00281
Location:3 → 237

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
NM_001355748.1 → NP_001342677.1 N6-Methyl-AMP deaminase isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate exons compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL845479

Consensus CDS

CCDS89543.1

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
NM_029475.2 → NP_083751.1 N6-Methyl-AMP deaminase isoform a

See identical proteins and their annotated locations for NP_083751.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). The 5' UTR of this variant is incomplete due to lack of a complete transcript and splice pattern ambiguity in the upstream region.

Source sequence(s)

AK048809, AK049697, BC050879

Consensus CDS

CCDS16633.1

UniProtKB/Swiss-Prot

A2ARU3, A2ARU4, Q80SY6, Q8BLN3, Q8BX67, Q9D4Q6

Related

ENSMUSP00000067133.6, ENSMUST00000066155.6

Conserved Domains (1) summary

cd00443
Location:17 → 344

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

120970525..120989921

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500351.3 → XP_006500414.1 adenosine deaminase-like protein isoform X1

See identical proteins and their annotated locations for XP_006500414.1

UniProtKB/Swiss-Prot

A2ARU3, A2ARU4, Q80SY6, Q8BLN3, Q8BX67, Q9D4Q6

Conserved Domains (1) summary

cd00443
Location:17 → 344

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_030252181.1 → XP_030108041.1 adenosine deaminase-like protein isoform X3

Conserved Domains (1) summary

cd00443
Location:1 → 230

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_006500352.4 → XP_006500415.1 adenosine deaminase-like protein isoform X1

See identical proteins and their annotated locations for XP_006500415.1

UniProtKB/Swiss-Prot

A2ARU3, A2ARU4, Q80SY6, Q8BLN3, Q8BX67, Q9D4Q6

Related

ENSMUSP00000113052.2, ENSMUST00000119031.8

Conserved Domains (1) summary

cd00443
Location:17 → 344

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_006500359.3 → XP_006500422.1 adenosine deaminase-like protein isoform X4

See identical proteins and their annotated locations for XP_006500422.1

UniProtKB/Swiss-Prot

Q80SY6

Related

ENSMUSP00000106290.3, ENSMUST00000110662.9

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_030252183.1 → XP_030108043.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_030252178.1 → XP_030108038.1 adenosine deaminase-like protein isoform X2

Conserved Domains (1) summary

cd00443
Location:1 → 277

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_036162657.1 → XP_036018550.1 adenosine deaminase-like protein isoform X3

Conserved Domains (1) summary

cd00443
Location:1 → 230

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_030252180.1 → XP_030108040.1 adenosine deaminase-like protein isoform X3

Conserved Domains (1) summary

cd00443
Location:1 → 230

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_036162658.1 → XP_036018551.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_030252179.1 → XP_030108039.1 adenosine deaminase-like protein isoform X3

Conserved Domains (1) summary

cd00443
Location:1 → 230

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_011239837.2 → XP_011238139.1 adenosine deaminase-like protein isoform X5

Conserved Domains (1) summary

cd00443
Location:17 → 380

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_030252182.1 → XP_030108042.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_006500360.3 → XP_006500423.1 adenosine deaminase-like protein isoform X4

See identical proteins and their annotated locations for XP_006500423.1

UniProtKB/Swiss-Prot

Q80SY6

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_006500353.5 → XP_006500416.1 adenosine deaminase-like protein isoform X1

See identical proteins and their annotated locations for XP_006500416.1

UniProtKB/Swiss-Prot

A2ARU3, A2ARU4, Q80SY6, Q8BLN3, Q8BX67, Q9D4Q6

Conserved Domains (1) summary

cd00443
Location:17 → 344

ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...
XM_036162661.1 → XP_036018554.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_036162660.1 → XP_036018553.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
XM_036162659.1 → XP_036018552.1 adenosine deaminase-like protein isoform X4

Conserved Domains (1) summary

cl00281
Location:3 → 201

metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...