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    ubiD 3-octaprenyl-4-hydroxybenzoate decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948326, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ubiD
    Official Full Name
    3-octaprenyl-4-hydroxybenzoate decarboxylase
    Primary source
    ECOCYC:EG11396
    Locus tag
    b3843
    See related
    ASAP:ABE-0012557
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3835; yigC; yigY
    Summary
    AFMB Structural Genomics target Number 3 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG11396]. 3-Octaprenyl-4-hydroxybenzoate decarboxylase catalyzes the third step in the biosynthesis of ubiquinone. [More information is available at EcoCyc: EG11396].
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    Genomic context

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    Sequence:
    NC_000913.3 (4024988..4026481)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene twin arginine protein translocation system - TatC protein Neighboring gene 3' -> 5' ssDNA/RNA exonuclease TatD Neighboring gene transcription antiterminator RfaH Neighboring gene NAD(P)H-flavin reductase Neighboring gene 3-ketoacyl-CoA thiolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of ubiquinone in Escherichia coli K-12: location of genes affecting the metabolism of 3-octaprenyl-4-hydroxybenzoic acid and 2-octaprenylphenol. Cox GB, et al. J Bacteriol, 1969 Aug. PMID 4897112, Free PMC Article
    2. Low ubiquinone content in Escherichia coli causes thiol hypersensitivity. Zeng H, et al. J Bacteriol, 1998 Jul. PMID 9658014, Free PMC Article
    3. Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli. Alexander K, et al. Biochemistry, 1978 Oct 31. PMID 365223
    4. The role of UbiX in Escherichia coli coenzyme Q biosynthesis. Gulmezian M, et al. Arch Biochem Biophys, 2007 Nov 15. PMID 17889824, Free PMC Article
    5. Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms. Meganathan R. Vitam Horm, 2001. PMID 11153266

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carboxy-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyl-FMNH2 binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquinone biosynthetic process from chorismate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3-octaprenyl-4-hydroxybenzoate decarboxylase
    NP_418285.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4024988..4026481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418285.1 3-octaprenyl-4-hydroxybenzoate decarboxylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418285.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9Q760, A0A8S7JTX9
      Conserved Domains (1) summary
      PRK10922
      Location:1 → 497
      PRK10922; 4-hydroxy-3-polyprenylbenzoate decarboxylase
    Nucleotide Protein
    Heading Accession and Version

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